Methandriol is a steroid that is very similar to the prohormone 5-androdiol except that it is C-17 alpha alkylated and also esterified at both ends. It is present in combination with several other steroids especially those manufactured in Australia. In Dan Duchaine’s Underground Steroid handbook II, Duchaine postulated that methandriol enhanced the activity of any steroid used in combination with it. He stated that methandriol did this by binding very strongly to SHBG thereby knocking other steroids into the free and active state (similar to what has been described for mesterolone). Although methandriol does bind to SHBG, it does so fairly weakly and is not capable of knocking most steroids off.
Methandriol is very prone to aromatization (like androdiol) and it has been suggested that it can bind directly to the estrogen receptor without the need for aromatization. When used with other aromatizing steroids, methandriol most likely occupies aromatase to the point that the other steroid is unable to be aromatized allowing it to stay free and active. While this sounds like a good idea at first, the excess estrogen that is produced by adding methandriol could lead to gynecomastia quickly.
Methandriol has been found to be a potent inhibitor of 11-beta hydroxylase.This results in a buildup of deoxycorticosterone, a potent mineralocorticoid that elicits retention of sodium and water resulting in hypertension.A potentially disturbing aspect of the hypertension induced with methandriol was its apparent irreversibility.The inhibition of 11-beta hydroxylase reduces the production of cortisol and results in a reduction in the size of the adrenals, also known as adrenal atrophy, which can result in a state of acute adrenal insufficiency upon withdrawal of the use of steroids that inhibit 11-beta hydroxylase.
Methandriol is metabolized to methyltestosterone, estrogenic metabolites and 5-alpha reduced androgens that contribute to the side-effect profile of this steroid.The “increase in efficacy” that this steroid induces when used in combination with other androgens as proposed by Duchaine and others may be related to the inhibition of 11-beta hydroxylase which will result in water weight gain and an anticatabolic effect through the reduction in serum cortisol. As mentioned elsewhere, the inhibition of 11-beta hydroxylase can cause hypertension and other negative cardiovascular effects.
Methandriol (or MAD) seems to be one of the more rare and exotic anabolic steroids. It is actually 5-androstenediol (5AD) that has had its chemical structure modified by adding a methyl group so the compound can resist being broken-down by the liver when taken orally. This results in better utilization by the body and is called 17-alpha alkylation (17AA). The first aspect that will be addressed is the one that most interests bodybuilders, the muscle building potential of the drug. With an anabolic (muscle building) effect of 20-60 (compared testosterone which has an anabolic rating of 100), not much muscle gain can be expected from MAD use. It is also slightly androgenic, again when compared to testosterone which has an androgenic effect of 100 MAD only rates 30-60.
Methandriol low androgenic properties may be a blessing and a curse, on one hand with its low androgenic effects the drug can be used without worries by prone individuals who suffer from prostate problems, hair loss and acne. It may also be used by female bodybuilders who wish to avoid the masculinizing side effects of androgens once they stick to a reasonable dosage and cycle duration.1 On the other hand the benefits of using an androgenic steroid are lost, there is a direct correlation between a drugs androgenic levels and strength gains, highly androgenic steroids also tend to aid in fat loss by binding strongly to the androgen receptor (A.R).
Methandriol Dipropionate is a injectable, strongly anabolic steroid with some androgenic properties. The usual dosage for Methandriol Dipropionate is 100 mg every 2-3 days.
By raising the level of nitrogen retention, Methandriol Dipropionate stimulates protein synthesis, resulting in greater muscle mass; and it increases strength. In addition, it may have anti-catabolic properties. Methandriol Dipropionate is strong enough to be used by alone. However, it is frequently combined with other steroids to enhance the overall effects. Methandriol dipropionate does not directly convert to estrogen, thus it has a low incidence of estrogen-related side effects, such as gynecomastia, water retention, and fat deposition, which are usually minimal if they occur. As Methandriol dipropionate has an androgenic component, typical androgenic-related side effects are possible: oily skin, acne, increased body hair, and scalp hair loss if prone to male pattern baldness.
The recommended dose for athletes is 100mg in 2 to 3 days. The recommended dose for oral form of Methandriol Dipropionate (M.D.) is 40 to 60mg per day. The oral form should not be taken for more than 6 weeks.
Methandriols parent hormone 5AD has been shown to be a steroid with "potent estrogenic properties"(6), since methylation makes a hormone more bio-available and thus "stronger" I am lead to believe that methandriols estrogenic activity is even more potent than 5AD. This alone is bad news for any Steriod.com members interested in adding this drug to a cycle, excessive estrogenic activity can lead to breast tissue growth in men (gynecomastia), fat gain, water retention, loss of sex drive, and sluggish natural testosterone production. Worse still is that 5AD itself activates the estrogen receptor (E.R.)(6) This would make aromatize inhibitors like letrozole (femera) and anastrozole (arimidex) a bit less effective in combating MAD estrogenic sides because it does not have to be exposed to the aromatize enzyme to do any harm.
More evidence that supports MAD has direct estrogenic properties is its use in veterinary injectables. Commonly used for promoting weight gain in animals(7), studies indicate combining anabolic steroids with female sex hormones (estrogen, progesterone) promote better weight gain that either alone(8)this especially holds true to when female sex hormones are stacked with the non-aromatizing nandrolone derivative trenbolone(9). MAD estrogenic properties would make it useful in this regard, this is the REAL reason MAD is added to other anabolic veterinary preparations, not because it sensitizes the A.R. Most of the profiles on methandriol says it gives "massive strength gains", however looking at the evidence it would seem the only "massive strength gains" from MAD could stem from the increased amount of water retention inside the muscles which would result in a rebound effect when the muscles are compressed during the lowering of a weight, similar to the action of a benching shirt.
Believe or not estrogen is a muscle building hormone as well, causing growth by attaching to the estrogen receptor on muscles (10) these are minor benefits however and are not worth the potential adverse sides. A common trait from using MAD is elevated blood pressure (11) this could be from the water retention due to high estrogenic activity or other actions in the body (11) There is no evidence that methandriol negatively effects cholesterol so your cardio vascular heath would be the least of your worries if you chose to use methandriol.
Methandriol is not directly aromatized by the body, although one of its known metabolites is methyltestosterone, which can aromatize. Methlyandrostenediol is also believed to have some inherent estrogenic activity. It is, likewise, considered a weakly to moderately estrogenic steroid. Gynecomastia is possible during treatment, but generally only when higher doses are used. Water and fat retention can also become issues, again depending on dose. Sensitive individuals may need to addition an anti-estrogen such as Nolvadex® to minimize related side effects.
Although often classified as an anabolic steroid, methylandrostenediol is sufficiently androgenic. Androgenic side effects are common with this substance. This may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Note that methylandrostenediol is not affected by 5-alpha reductase, so the relative androgenicity of this steroid is not affected by the concurrent use of finasteride or dutasteride.
Methandriol is a c17-alpha alkylated compound. This alteration protects the drug from deactivation by the liver, allowing a very high percentage of the drug entry into the bloodstream following oral administration. C17-alpha alkylated anabolic/androgenic steroids can be hepatotoxic. Prolonged or high exposure may result in liver damage. In rare instances life-threatening dysfunction may develop. It is advisable to visit a physician periodically during each cycle to monitor liver function and overall health. Intake of c17-alpha alkylated steroids is commonly limited to 6-8 weeks, in an effort to avoid escalating liver strain. Injectable forms of the drug may present slightly less strain on the liver by avoiding the first pass metabolism of oral dosing, although may still present substantial hepatotoxicity.
The use of a liver detoxification supplement such as Liver Stabil, Liv-52, or Essentiale Forte is advised while taking any hepatotoxic anabolic/androgenic steroids.
Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Methylandrostenediol has a strong effect on the hepatic management of cholesterol due to its structural resistance to liver breakdown and (with the oral) route of administration. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.
To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.
All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.
The above side effects are not inclusive. For more detailed discussion of potential side effects, see the Steroid Side Effects page.
→ Visit our online pharmacy and fill in an order of Methandriol raw materials.
→ Define place of delivery, quantity of the product and the way of payment.
→ In the period of 30 minutes, you will receive a confirmation of your order.
→ It will be sent out within 12 hours.
|White or off white or light yellow crystalline powder|
|Insoluble in water or alcohol, soluble in Acetic acid, ethyl ester|
1) Quality Standard: USP 35
2) Purity: >99%
3) We are manufacturer and can provide high quality products with factory price.
1) Parcel can be sent out in 24 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice.
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Market feedback and goods feedback will be appreciated, meeting customers' requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
1)Safe delivery: Channel diversification,protect the privacy of customers.And just in case, ensure to re-ship.
2)Never change: The product will always maintain high purity, will not change,High quality is the culture of our company.
3)Good services: As quickly as possible to solve customer problems, so that customers receive the goods safely.