Cetilistat is a drug designed to treat obesity. It acts in the same way as the older drug orlistat (Xenical) by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are excreted undigested.
Cetislim, also known as Cetilstat, is a weight loss medicine may be prescribed for those that are significantly overweight. It works by blocking fat so it isn’t digested or absorbed into the body. It is classified as an Lipase Inhibitor. It works with the digestive system to block an enzyme called Lipase that the body needs for fat to be digested. It is similar to Xenical (Orlistat) but is better tolerated by most people.
In human trials, cetilistat was shown to produce similar weight loss to orlistat, but also produced similar side effects such as oily, loose stools, fecal incontinence, frequent bowel movements, and flatulence. It is likely that the same precautions would apply in that absorption of fat-soluble vitamins and other fat-soluble nutrients may be inhibited, requiring vitamin supplements to be used to avoid deficiencies.
Cetilistat has completed Phase 1 and 2 trials in the West and is currently in Phase 3 trials in Japan where it is partnered with Takeda. Norgina BV has now acquired the full global rights to cetilistat from Alizyme after the latter went into administration.
Cetislim (Cetilistat) is a weight loss drug used in combination with a low calorie diet. It works by blocking a substantial amount of fat from being digested and absorbed into the body. This medicine is classified as a lipase inhibitor and it works directly on the digestive system where it blocks the action of a lipolytic enzyme called lipase. These lipases are what the body uses to digest the fat.
The goal of Cetislim is to offer a two way method of losing weight and getting healthier. First, it blocks the fat as mentioned above. Second, this method of weight loss is combined with a low calorie diet with many food restrictions. The idea is to also prevent the body from taking in more foods that could be turned into fat. By giving the body food it can use for fuel a person has more energy and it boosts metabolism.
In addition to using the medication and the diet, a person needs to develop better overall lifestyle habits. This includes eating right, portion control, and daily exercise. A customized plan of action can be developed between the patient and the doctor.
Before using Cetilistat, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.
Consult your doctor if suffering from diabetes or taking other herbal or nutritional products
Eat a healthy, low-fat diet and excercise while taking this medication
Follow exercise and low fat diet while taking this drug
If taking levothyroxine and/or cyclosporine, separate administration of those drugs and this drug by at least 4 hours
Take the capsule within 1 hour after or during the course of a main meal.
Cetislim containing the active ingredient cetilistat is considered a lipase inhibitor type of medication. The medication works by blocking the metabolization of fat within food so you do not digest it and the undigested fat will be passed through the body in bowel movement. The capsules should be used along with a low calorie, low fat diet and a proper exercise program to treat obesity. Reducing calorie intake and weight maintenance can help prevent and treat conditions such as high cholesterol, diabetes, hypertension and heart disease.
Cetislim is usually taken orally as directed by a doctor. The medication can be taken with, during or even up to 1 hour after each main meal. If you skip a meal, do not take the medication. Swallow the capsules whole with a glass of water. Contact a doctor for the correct dosage and length of treatment as it will depend on the patients condition and their response to the therapy.
Cetislim (Cetilistat) is provided as 60mg strength capsules for administration orally. The medicine is taken with meals to ensure that it can work while the food is being digested, so that the absorption of fat from the diet can be effectively reduced. Your physician will advise you on how much medicine to take with each dose, as well as the required daily dosage. It is very important that you adhere to these instructions. Do not take more than your physician tells you to take.
Cetislim capsules are offered in 60 mg strength. The dose is to take one capsule with each meal. Don’t skip meals and don’t take more of the medication than prescribed. Taking Cetislim with food can help to block the fat from what you eat from being absorbed into the body. Make sure you work with your doctor to ensure the right foods are eaten and you are taking this medication as you should.
It is not recommended to take more than 3 capsules within 24 hours.
Immediately proceed to your nearest emergency department if you suffer an allergic reaction. Symptoms usually associated with such a reaction include difficulty breathing or swallowing, chest tightness, swelling, skin rashes, and hives.
Cetislim is not always suitable for all patients. Always consult your health care provider prior to using this medication if you are pregnant, breastfeeding, trying to conceive, using any other medication (prescription or non-prescription), using any herbal products or supplements, or if you have any allergies or other health problems.
The correct dosage and prescription commonly depend on the patient and the condition being treated. Do not adjust your dosage without the approval of your health care provider. This product is only for use as prescribed and instructed.
Although Cetislim (Cetilistat) can help overweight patients lose weight and therefore reduce the risk of diabetes or other serious conditions associated with obesity, you will also be advised by your physician to eat a low calorie diet and to exercise regularly.
Eating foods high in fat will increase the side effects mentioned above. Such a diet can also result in serious abdominal pain and indigestion. Make sure you only engage in physical activity your doctor says you are able to do. As your level of fitness increases and your weight decreases you can add more difficult physical activity to the mix.
Individuals with diabetes or heart problems may not be able to take this medication. Make sure you consult with your doctor about all of your health concerns. They also need to know any medications or herbal supplements you already take.
Patients using Cetislim may encounter unwanted side effects such as:
Gas with discharge
Poor bowel control
Increased number of bowel movements
Urgent need to have bowel movement
Oily or fatty stools
Contact a doctor immediately should side effects persist or encounter more severe side effects such as:
Dark colored urine
Pain in upper right part of stomach
Loss of appetite
Severe stomach pain
Difficulty breathing or swallowing
Patients undergoing treatment for obesity with Cetislim (Cetilistat) could suffer from side effects. You must inform your physician if this happens. Some examples are given here:
Steatorrhea (oily stools)
Spotting of the underwear
Problems controlling bowel movements
Although mild reactions are generally considered to be more common, serious adverse events may also occur. Consult your physician immediately should this occur.
Please discuss the risks and benefits with your doctor.
users have most commonly reported consuming Cetilistat before food. However, this may not be reflective of how you should consume this medicine. Please follow your doctor's advice on how you should use this medicine. to find out what other patients report as timing of using Cetilistat.
4. Is it safe to drive or operate heavy machinery when consuming?
If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Cetilistat medicine then it may not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Please check for these effects on your body when using Cetilistat. Always consult with your doctor for recommendations specific to your body and health conditions.
Most medicines don't come with a potential for addiction or abuse. Usually, government's categorizes medicines that can be addictive as controlled substances. Examples include schedule H or X in India and schedule II-V in the US. Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines. Lastly, do not self-medicate and increase your body's dependence to medicines without the advice of a doctor.
Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.
In case you miss a dose, use it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not use extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.
Do not use more than prescribed dose. Taking more medication will not improve your symptoms; rather they may cause poisoning or serious side-effects. If you suspect that you or anyone else who may have overdosed of Cetilistat, please go to the emergency department of the closest hospital or nursing home. Bring a medicine box, container, or label with you to help doctors with necessary information.
Do not give your medicines to other people even if you know that they have the same condition or it seems that they may have similar conditions. This may lead to overdosage.
Please consult your physician or pharmacist or product package for more information.
Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.
Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Cetilistat.
Taking a single dose of expired Cetilistat is unlikely to produce an adverse event. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Expired drug may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use expired drug. If you have a chronic illness that requires taking medicine constantly such as heart condition, seizures, and life-threatening allergies, you are much safer keeping in touch with your primary health care provider so that you can have a fresh supply of unexpired medications.
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