DMAA (1,3-dimethylamylamine) is an amphetamine derivative that has been widely used in sports supplements sold in the United States. Also known as methylhexanamine or geranium extract, DMAA is often touted as a “natural” stimulant, with many claimed functional uses including a body-building aid, an athletic performance enhancer, and a weight-loss aid. Although DMAA at one time was approved as a drug for nasal decongestion, no medical use of DMAA is recognized today. FDA is not aware of any reliable science indicating that DMAA exists naturally in plants.
DMAA-containing dietary supplements are illegal and their marketing violates the law. Based on the scientific information reviewed by FDA, DMAA is not a dietary ingredient.
Dimethylamylamine is a drug made synthetically in a laboratory. It was originally used as a nasal decongestant.
Today, dimethylamylamine is sold as a dietary supplement used for attention deficit-hyperactive disorder (ADHD), weight loss, improving athletic performance, and body building Methylhexanamine, commonly known as 1,3-dimethylamylamine or DMAA, was invented and developed by Eli Lilly and Company and was marketed by Lilly as an inhaled nasal decongestant pharmaceutical drug from 1944 until Lilly voluntarily withdrew it from the market in 1983. Methylhexanamine is an indirect sympathomimetic drug.
Since 2006 methylhexanamine has been marketed extensively under many names as an energy-boosting dietary supplement under the claim that it is similar to certain compounds found in geraniums, but its safety has been questioned as a number of adverse events and at least 5 deaths have been associated with methylhexanamine-containing supplements. It has been banned by many sport authorities and governmental agencies.
Some products claim that dimethylamylamine naturally comes from rose geranium oil. Supplements that contain this ingredient sometimes list rose geranium, geranium oil, or geranium stems on the label. However, laboratory analysis shows that this drug probably does not come from this natural source.
It is thought that these manufacturers have artificially added this drug to the supplement rather than obtaining it from a natural source. Dimethylamylamine is considered a drug in Canada is not permitted in dietary supplements or natural health products.
Many athletes take dimethylamylamine to improve performance. However, dimethylamylamine was added to the World Anti-Doping Agency’s prohibited substances list for 2010. Therefore, competitive athletes should avoid taking it.
Dimethylamylamine is thought to have stimulant effects similar to decongestants such as pseudoephedrine, ephedrine, and others. Some promoters say that it is a safer alternative to ephedrine. However, there is no scientific information to back up this claim.
1,3-dimethylamylamine (DMAA) is a synthetically produced neural stimulant used as a key ingredient in dietary supplements to improve athletic performance and provide increased energy. In terms of chemical structure, it is similar to Ephedrine.
It is also known as methylhexanamine and can be traded under the names Forthane and Geranamine.
Although originally introduced as a nasal decongestant, it is now used for a variety of reasons including as a supplement for enhancing athletic performance, weight loss, and attention deficit-hyperactive disorder (ADHD). Some bodybuilders use DMAA as a pre-workout stimulant as well.
Based on some of the claims made by the manufacturers of DMAA-based products or supplements, 1,3-dimethylamylamine can be said to primarily serve as a central nervous system stimulant. The potential benefits of these products are primarily related to an enhancement of the cognitive ability.
In simple terms, the use of 1,3-dimethylamylamine may lead to an increase in energy and focus. It is due to these purported benefits that many students and professional workers use DMAA products for heightened senses and an increase in focus.
Since DMAA-based products may lead to a release of dopamine, they can also lead to a sensation of temporary euphoria. This includes an improved mood and a general feeling of happiness.
Some bodybuilders and weight training athletes use 1,3-dimethylamylamine supplements as well. The energy release functions of DMAA products make them an effective pre-workout support. The enhanced cognitive ability, in addition to the increased strength, can provide an added focus and motivation.
The enhanced focus and energy can further increase tolerance to pain and improve stamina. This provides valuable support during intense workout sessions.
Research suggests the use of 1,3-dimethylamylamine may cause vasoconstriction. This means that the blood vessels are constricted to increase blood pressure. This occurs without a corresponding increase in the heart rate.
The increased blood pressure can stimulate muscle growth at lower intensity levels. But the level of increase in blood pressure depends upon the dosage.
Before using DMAA to stimulate increase in mental energy and focus, it is important to read the dosage recommendations by the manufacturer. Its overuse may lead to adverse effects.
For best results, DMAA should not be consumed on a daily basis. Instead, you can use it as a part of a cycle with the periods of use evenly spaced out and interspersed with periods of non-use. The goal, here, is to avoid dependence on DMAA supplements.
A common lower dosage range of 1,3-dimethylamylamine based supplement or product is around 10-20 mg and it can eventually reach higher ranges of up to 40-60 mg.
You should note, however, that these dosage ranges are not based on any form of scientific evidence. Instead, these values are derived from usage recommendations of the manufacturers of DMAA supplements available in the market.
It is typically used half an hour before the workout, study session, or any other time when your body requires extra energy or sharper focus. You may take up multiple low doses in a day.
However, one daily administration is often considered enough.
After the dosage, the effects may last up to many hours. After that, some people may experience an energy ‘crash’ in which a sudden drop in energy levels may be observed.
Some people may also find that the effects of using DMAA products are too over-powering and are do not improve brain function. Instead of enhanced focus, some users may experience increased anxiety which makes it even harder to focus than usual.
It is due to some of the potential adverse affects that the Food and Drug Administration (FDA) has deemed DMAA products unsafe and advises consumers not to purchase any dietary supplement containing DMAA.
Due to the lack of substantial and authoritative scientific research on 1,3-dimethylamylamine, the effects of DMAA-based products are not fully understood. However, according to some of the claims, DMAA is primarily responsible for the release of norepinephrine.
Norepinephrine is among the neurotransmitters that, when released, may lead to increase in the levels of energy, focus, attention, and mental alertness.
When entered into the body, 1,3-dimethylamylamine passes the intestinal tract to be absorbed in the bloodstream. It travels along the bloodstream, crosses the blood brain barrier and enters the central nervous system to stimulate the release of neurotransmitters.
Some manufacturers also claim that 1,3-dimethylamylamine also stimulates the release of another powerful neurotransmitter, dopamine, which is a mood enhancing agent.
DMAA, also known as 1,3-dimethylamylamine, methylhexanamine or geranium extract, is an ingredient found illegally in some dietary supplements and often touted as a “natural” stimulant. DMAA, especially in combination with other ingredients such as caffeine, can be a health risk to consumers.
Ingestion of DMAA can elevate blood pressure and lead to cardiovascular problems ranging from shortness of breath and tightening in the chest to heart attack. Dietary supplements containing DMAA are illegal and FDA is doing everything within its authority to remove these products from the market.
In 2012, FDA issued warning letters to companies notifying them products with DMAA need to be taken off the market or reformulated to remove this substance. Most companies warned are no longer distributing products with DMAA. While FDA is working to get these products off the market, consumers should not buy or use any dietary supplement product containing DMAA.
The FDA has stated that methylhexanamine "is known to narrow the blood vessels and arteries, which can elevate blood pressure and may lead to cardiovascular events ranging from shortness of breath and tightening in the chest to heart attack." Numerous adverse events and at least 5 deaths have been reported in association with methylhexanamine-containing dietary supplements.
A study published in the Journal of Nutrition and Metabolic Insights involving 25 males discovered that a sports supplement generally known as Jack3D that contained DMAA didn’t significantly increase blood pressure or resting heart rate. They on top of that documented more than the 10-week program of the analysis, the participants acquired a modest loss in LDL-cholesterol.
DMAA can on top of that bring about migraine headaches in those who are susceptible to them as a result of its vasoconstrictive results.
Simply because of its vasoconstrictive effects, DMAA may cause erectile dysfunction. DMAA decreases production of nitric oxide, a chemical that expands blood vessels so they generate more blood flow. Reduce levels of nitric oxide generally is a condition when it comes to getting and keeping an erection. Fortunately, a very small percentage of adult males endure this side effect.
Athletes and bodybuilders are constantly in search of an advantage when it comes to sports performance and building lean body mass. Some turn to dietary and sports improving supplements to boost their athletic performance or lose body fat.
One such supplement ingredient called methylhexamamine or DMAA is advertised for this objective and is currently the topic of some controversy.DMAA was initially earmarked by the drug company Eli Lilly as a attainable treatment for nasal congestion and asthma. In the event the trademark expired, it absolutely was presented as a dietary supplement in 2006 under the name Geranamine.
Considering that time it’s grown in popularity, especially after ephedrine, a stimulant found in some appetite suppressants and thermogenic supplements, was banned. You can find DMAA within a variety of sports supplements offered at fitness food stores and on the net.
DMAA has stimulant results significantly like caffeine. Individuals who take it experience more energy and have better mental focus without any the jitteriness that many people experience when they drink an excessive amount of caffeine.
At exactly the same time, DMAA causes constriction of blood vessels and dilation of bronchioles in the lungs, that is certainly why Eli Lilly looked at it as a feasible asthma treatment. It’s also an appetite suppressant and may cause weight loss in some people.
The FDA warns consumers about the variety of potential side effects caused by the use of DMAA-based products. According to the FDA, the vasoconstriction or the narrowing of blood vessels caused by 1,3-dimethylamylamine can lead to cardiovascular problems such as heart attack, seizures, shortness of breath, and tightening in the chest.
Although the consumption of 1,3-dimethylamylamine leads to a spike in energy levels, some users report a subsequent rapid drop or ‘crash’ in these energy levels a few hours after its use. Along with the drop in energy levels, the crash may also lead to a change in mood.
Other potential adverse effects, according to the FDA, may include arrhythmias, neurological conditions, psychiatric disorders, nervous system disorders and, in certain extreme cases, even death.
However, it should be noted that research suggests that many of the adverse outcomes associated with the use of DMAA-based products are simply due to the overuse of the product. These effects can be avoided by sticking to the regular dosage range of around 25-75 mg at a time.
To avoid some of the side effects of DMAA-based products, bodybuilders and weight trainers, should opt for foods with high protein content instead.
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|slightly soluble in water, but soluble in diluted HCl and many polar solvents|
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