The article mainly talks about a family member of the sex hormones --Fliban se ri n.
Flibanserin known as the "female Viagra", increases sexual desire in women. Unlike Viagra, flibanserin is believed to work by restoring brain chemical balance.For the drug itself, it can be used as a function to improve women's function,as well as the introduction of specialized drugs.
No. Flibanserin doesn’t contain estrogen or testosterone or any other hormone. Flibanserinis a psychotropic medication. It acts specifically on serotonergic neurons in the brain, and has indirect effects on dopamine and norepinephrine.
Serotonin in the brain is generally thought to put the brakes on sex. Flibanserin may help ease up on the serotonin braking system, so libido can get going again.
Flibanserin, known as the "female Viagra", is a prescription medication used to enhance sexual desire and decrease emotional distress in premenopausal women with hypoactive sexual desire disorder (HSDD). HSDD is the most commonly reported sexual dysfunction in women.
Although flibanserin has been called "the female Viagra", the way in which it works is distinctly different from Viagra. Viagra works by increasing blood flow to the genitals, whereas flibanserin may work more like an antidepressant by correcting an imbalance of neurotransmitters in the brain to help restore sexual desire. It has effects on dopamine, norepinephrine, and serotonin levels in the brain.
Flibanserin comes as a tablet and is typically taken daily, at bedtime.
Common side effects of flibanserin include dizziness, nausea, and sleepiness. Flibanserin can also cause fainting, especially when used with alcohol.
Flibanserin raw powder,the material of Flibanserin,a kind of White crystalline powder,many steroids products supplier usually buy high purity Flibanserin powder online,make it into all kinds of brand finished Flibanserin,the detail of the Flibanserin raw in SZOB as below:
Molecular Formula: C20H21F3N4O
Molecular Weight: 390.4
Melt Point: 225°C
Storage Temp.: RT
Color: White crystalline powder
Flibanserin is an oral drug used for treating low sexual desire in women. The mechanism of action of flibanserin is not completely understood. Flibanserin affects the way the brain works by interfering with communication among the brain's nerves in areas of the brain that control sexual desire and other pleasurable sensations.
Nerves communicate with each other by making and releasing chemicals called neurotransmitters. The neurotransmitters travel to other nearby nerves where they attach to receptors on nerves. The attachment of neurotransmitters either stimulates or inhibits the function of the nearby nerves. Flibanserin blocks several of the receptors on nerves including dopamine type 4, and serotonin type 2A, 2B and 2C receptors.
It also stimulates serotonin type 1A. How these effects improve sexual desire in women is unknown. Scientists think that flibanserin may regulate areas of the brain that control sexual desire in premenopausal women with reduced sexual interest and desire. The FDA approved flibanserin on August 18, 2015.
The clinical trials data presented to the FDA on flibanserin included results from over 11,000 patients — one of the largest data-sets ever presented in the FDA’s history. The safety of this medication has been evaluated more stringently than that of most new drugs approved by the FDA.
That being said, there is still much that is unknown about flibanserin — as with any other recently-approved medication. Rare but serious side effects are sometimes only discovered after a drug has been in general use for months or years. So expect your prescriber to monitor your treatment carefully.
Flibanserin is used to treat women with hypoactive sexual desire disorder (HSDD; a low sexual desire that causes distress or interpersonal difficulty) who have not experienced menopause (change of life; the end of monthly menstrual periods). Flibanserin should not be used for the treatment of HSDD in women who have gone through menopause or in men or to improve sexual performance. Flibanserin is in a class of medications called a serotonin receptor 1A agonist/serotonin receptor 2A antagonist. It works by changing the activity of serotonin and other natural substances in the brain.
Flibanserin comes as a tablet to take by mouth. It is usually taken once daily at bedtime. Take flibanserin at bedtime every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take flibanserin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.If your symptoms do not improve after 8 weeks of treatment, call your doctor.
tell your doctor and pharmacist if you are allergic to flibanserin, any other medications, or any of the ingredients in flibanserin tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: antidepressants such as fluoxetine (Prozac, Sarafem); antifungals; cimetidine (Tagamet); digoxin (Lanoxin); diphenhydramine (Benadryl);
medications for anxiety or mental illness; medications for seizures such as carbamazepine (Epitol, Tegretol, Teril, others), phenobarbital, and phenytoin (Dilantin, Phenytek); opiate (narcotic) medications for pain control; oral contraceptives; proton pump inhibitors including dexlansoprazole (Dexilant), esomeprazole (Nexium, Vimovo), lansoprazole (Prevacid), omeprazole (Prilosec),
pantoprazole (Protonix), or rabeprazole (Aciphex); ranitidine (Zantac); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); sedatives; sirolimus (Rapamune); sleeping pills; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
tell your doctor what herbal products you are taking, especially ginkgo, resveratrol, and St. Johns wort.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking flibanserin, call your doctor. Do not breast-feed while taking flibanserin.
you should know that flibanserin may make you drowsy. Do not drive a car or operate machinery until at least 6 hours after your dose of flibanserin and until you know how this medication affects you.
While taking Flibanserin
While you take Flibanserin,please pay attention to this:
Flibanserin and Alcohol
Consuming alcohol while taking flibanserin can cause dangerous reactions.
Avoid drinking alcohol while taking this medicine.
Flibanserin and Grapefruit
While you take Flibanserin,don't take Grapefruit,or talk to your doctor before consuming grapefruit or grapefruit juice while taking flibanserin.The fruit might interact with how the drug works in your body.
Don't drive or perform activities that require alertness until you know how this medicine affects you.Flibanserin may impair your thinking or reactions. Avoid driving or operating machinery for at least 6 hours after you take flibanserin, and until you know how this medicine will affect you. Dizziness or low blood pressure can cause falls or other accidents.
Avoid taking an herbal supplement containing: ginkgo, resveratrol, or St. John's wort.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
After taking Flibanserin,it's important to hopw how to store and dispose it,now let's learn.
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community.
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.
Taking this medicine with other drugs that make you sleepy or lower your blood pressure can worsen this effect. Ask your doctor before taking flibanserin with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
Tell your doctor about all your current medicines and any you start or stop using, especially:
St. John's wort.
This list is not complete. Other drugs may interact with flibanserin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
100 mg orally once per day at bedtime
Duration of therapy: This drug should be discontinued after 8 weeks if the patient does not report an improvement in symptoms.
Comments: This drug is not indicated to enhance sexual performance, and is not indicated for treatment in postmenopausal women or in men.
Use: Treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is not due to a co-existing medical or psychiatric condition, problems within the relationship, or the effects of a medication or other drug substance.
Renal Dose Adjustments
Data not available.
Liver Dose Adjustments
Contraindicated in patients with hepatic impairment.
If Initiating this Drug Following Use of Moderate or Strong CYP450 3A4 Inhibitor:
-Start this drug 2 weeks after the last dose of the CYP450 3A4 inhibitor.
If Initiating a Moderate or Strong CYP450 3A4 Inhibitor Following Use of This Drug:
-Start the CYP450 3A4 inhibitor 2 days after the last dose of this drug.
If you suspect an overdose, contact a poison control center or emergency room immediately.You can get in touch with a poison control center at 800-222-1222.
If you miss a dose of flibanserin, take your next dose at bedtime on the next day.
Don't double up on doses or take extra medicine to make up for a missed dose.
Use with alcohol increases risk of severe hypotension and syncope; therefore, alcohol use is contraindicated
Before prescribing flibanserin, assess the likelihood of the patient abstaining from alcohol, taking into account the patient’s current and past drinking behavior, and other pertinent social and medical history
Counsel patients who are prescribed flibanserin about the importance of abstaining from alcohol use
Because of the increased risk of hypotension and syncope is due to an interaction with alcohol, flibanserin is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called the ADDYI REMS Program
Contraindicated with moderate or strong CYP3A4 inhibitors
Coadministration with moderate or strong CYP3A4 inhibitors increases flibanserin concentrations, which can cause severe hypotension and syncope
Therefore, the use of moderate or strong CYP3A4 inhibitors is contraindicated
Contraindicated in patients with hepatic impairment
Contraindicated for use with any degree of hepatic impairment
Flibanserin exposure increased 4.5-fold in patients with hepatic impairment, compared with those with normal hepatic function, increasing the risk of hypotension, syncope, and CNS depression
Common Side Effects of Flibanserin
Tell your doctor if any of the following side effects become severe or don't go away:
Serious Side Effects of Flibanserin
Tell your doctor right away if you experience any of the following serious side effects:
Fainting or loss of consciousness
Severe dizziness or sleepiness
Signs of very low blood pressure (may include lightheadedness, nausea, clammy skin, blurry vision, depression, or dizziness)
This list didn’t include all the side effects,please check detaiks when you decide to take it.
How to buy Pharmaceutical Grade Flibanserin powder from SZOB raw company?
→ Visit our online pharmacy and fill in an order of Flibanserin raw materials.
→ Define place of delivery, quantity of the product and the way of payment.
→ In the period of 30 minutes, you will receive a confirmation of your order.
→ It will be sent out within 12 hours.
|insoluble in water, sparingly soluble in methanol, ethanol, acetonitrile and toluene, soluble in acetone, freely soluble in chloroform, and very soluble in methylene chloride.|
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