Flumethasone is used to treat certain types of outer ear infections. It helps to reduce swelling, itching, redness, and discomfort in the ear. This ear drop contains both flumethasone, an anti-inflammatory corticosteroid, and clioquinol, an antibiotic that stops the growth of certain bacteria and fungi. This medication treats only certain types of bacterial and fungal ear infections. It will not work for other types of ear infections. Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness. This medication should not be used in children younger than 2 years.
Synonym: 6α,9α-Difluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 6α,9α-Difluoro-16α-methylprednisolone, 6α-Fluorodexamethasone.
Flumetasone (INN; or flumethasone) is a corticosteroid for topical use. Trade names include Locacorten, Locorten, and Orsalin. It is available in combination with clioquinol, under the trade name Locacorten-Vioform (in some countries Locorten-Vioform), for the treatment of otitis externa and otomycosis.Hot tags: Ceritinib . It is usually formulated as the pivalic acid ester prodrug flumetasone pivalate. Flumethasone is 420 times as potent as cortisone in an animal model for anti-inflammatory activity.
Flumethasone is a glucocorticoid receptor agonist. This complex binds to the nucleus causing a variety of genetic activation and repressions. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes.
The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Flumethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin.
Flumethasone pivalate is a topical difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. A prompt decrease in inflammation, exudation and itching is experienced after application. It is commonly used in veterinary practice1 and has been used in cortiso assays to study early porcine conceptus development.
Ear drops containing flumetasone and clioquinol are used to treat inflammation of the outer ear, especially if it is thought an infection is causing the swelling. This happens in ear conditions such as otitis externa. Flumetasone reduces the inflammation, and clioquinol treats the infection。
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about the drops and will provide you with a full list of any side-effects which you may experience from using them.Wash your hands before you begin.
Gently clean your ear with warm water and pat it dry.
Remove the cap from the bottle of ear drops.
Lie down, or tilt your head a little, so that the affected ear is facing upwards.
Gently pull down on your earlobe to straighten the ear canal.
Hold the container upside down near to the ear. Try not to touch the inside of your ear as you do this.
Apply enough pressure to release two or three drops from the dropper into your ear.
Keep your ear facing upwards for a few minutes to allow the solution to come into contact with the affected area.
Repeat the process in your other ear if you have been asked to use the drops in both ears.
Replace the cap on to the bottle of drops.
This medication is for use only in the ear. For best results, the ear canal should be clean and dry before using this medication. Ask your doctor for instructions on how to properly clean the ear and how to use an ear syringe with a soft rubber bulb if needed. Apply this medication into the ear, usually twice daily or as directed by your doctor. Do not use this medication more often or for longer than prescribed.
The length of treatment is usually not more than 10 days. To make sure that the right amount of medication is given, and to avoid touching the ear with the dropper, have another person give the drops if possible. To lower the risk of dizziness, hold the container in your hand for a few minutes to warm it. To apply ear drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your ear or any other surface.
Lie on your side or tilt the affected ear upward. Hold the dropper directly over the ear and place the prescribed number of drops into the ear canal. To help the drops roll into the ear of an adult, hold the earlobe up and back. In children, hold the earlobe down and back. Keep the head tilted for about 2 minutes, or insert a soft cotton plug in the ear if so directed. Repeat for the other ear if so directed. Do not rinse the dropper. Replace the cap after use.
Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same times each day. Continue using it for the full time prescribed, even if symptoms disappear after a few days. Stopping this medication too early may allow bacteria and fungi to continue to grow, which may result in a return of the infection. Do not use in the eye. Tell your doctor if your condition does not improve within 1 week or if it worsens.
Instill 2 or 3 drops twice daily directly into the auditory canal of the affected ear. Treatment should be limited to 7-10 days.
If there is little improvement after 7 days treatment with this medicine, appropriate microbiological investigations should be carried out and local or systemic antibiotic treatment given.
In case you miss a dose, use it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not use extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.
overdosage: Do not use more than prescribed dose. Taking more medication will not improve your symptoms; rather they may cause poisoning or serious side-effects. If you suspect that you or anyone else who may have overdosed of Flumethasone, please go to the emergency department of the closest hospital or nursing home. Bring a medicine box, container, or label with you to help doctors with necessary information.
Do not give your medicines to other people even if you know that they have the same condition or it seems that they may have similar conditions. This may lead to overdosage.
Please consult your physician or pharmacist or product package for more information.
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you (or your child) start using the drops it is important that your doctor knows:
If you have a burst (perforated) eardrum.
If you are pregnant or breast-feeding.
If you have ever had an allergic reaction to a medicine, or to any other ear drops. It is particularly important that you tell you doctor if you have ever had a bad reaction to iodine.
If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
Use the drops exactly as you have been advised by your doctor. Your doctor will recommend you use the drops twice a day, morning and evening. Try not to miss any doses. If you forget to put the drops in at the usual time, do it as soon as you remember.
Be careful not to spill any of the drops on your clothing or your hair, as they may stain.
Do not try to clean inside your ear with cotton buds. If you stick buds or other objects into your ear they can damage and irritate the inflamed skin, and make things worse. Just wipe the outside of your ear with a clean cloth or tissue if any discharge appears.
You will be prescribed a short course of treatment (no more than 7-10 days). If you feel your symptoms are no better after a week of using the drops, make another appointment to see your doctor for advice.
Store at room temperature between 59-86 degrees F (15-30 degrees C) away from heat, light, and moisture. Keep the bottle tightly closed. The solution may turn yellow when it is exposed to air, but it is still safe to use. It may stain hair, skin, and clothing. Do not store in the bathroom. Keep all medicines away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
Before using this medication, tell your doctor or pharmacist if you are allergic to flumethasone or other corticosteroids (e.g., prednisone); or to clioquinol or related antibiotic/anti-fungal drugs ; or to iodine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.
Talk to your pharmacist for more details. This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: a hole/perforation in the eardrum, skin reactions/infections (e.g., caused by vaccines, tuberculosis, syphilis, viruses such as chickenpox or herpes). Before using this medication, tell your doctor or pharmacist your medical history.
This medication may stain clothes, skin, nails, or hair. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.
Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.
Clioquinol may interfere with certain laboratory tests (e.g., thyroid tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug. This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use.
Keep a list of all your medications with you, and share the list with your doctor and pharmacist Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction:
itching/swelling (especially of the face/tongue/throat)
This is not a complete list of possible side effects.
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