LGD-4033, better known as Anabolicum is a Selective Androgen Receptor Modulator (SARM) that like testosterone is anabolic but without the effects that display significantly outside muscle tissue. Ligand Pharmaceuticals, ligand, referring to functional binding molecules, developed LGD-4033. Ligand Pharmaceuticals has made a name for itself with SARM research along with GTx, the two representing the bulk of SARM creation over the past decade.
LGD-4033 is one of the newer SARMS that has come out. It is a non-steroidal oral SARM that binds with AR which produces steroid-like results minus the steroids. It is the closest SARM that can be equated to an anabolic in terms of strength. LGD-4033 is the strongest of all the SARMS in terms of the size you can gain.
It’s in a group of androgen receptor (AR) ligands that are tissue selective, created to cure muscle wasting linked with acute and chronic diseases, age-related muscle loss and cancer. LGD-4033 is anticipated to yield the healing benefits of testosterone with better safety, admissibility and patient acceptance due to tissue-selective mechanism of action and its oral form of administering.
LGD-4033 is a selective androgen receptor modulator (SARMS), and a novel non-steroidal oral SARM that binds to AR with high affinity (Ki of ~1 nM) and selectivity. It's in a class of androgen receptor (AR) ligands that is tissue selective, developed to treat muscle wasting associated with cancer, acute and chronic illness and age-related muscle loss. LGD-4033 is expected to produce the therapeutic benefits of testosterone with improved safety, tolerability and patient acceptance due to tissue-selective mechanism of action and an oral route of administration.
Anabolicum is a SARM that binds tightly to the androgen receptors, primarily those of muscle and bone. Attaching to the androgen receptors, this creates enhanced anabolic activity in the body (muscle building) and has also been shown to be anti-catabolic (muscle wasting).
Test 600x Studies have shown Anabolicum to hold significant effects on bone deterioration through a strengthening effect. Along with its muscle building and bone strengthening properties, unlike anabolic steroids that attach to the androgen receptor, there is no activity presented outside the target muscle and bone areas of the body or at least only minimally.
LGD-4033 works by tying androgen receptors selectively. It shows anabolic activity in the bones and muscles instead of harmfully affecting the prostate and sebaceous glands which usually happens when using steroids.
LGD-4033 just concluded a study called Phase I Multiple Ascending Dose which included fit volunteers.
This was an unplanned, double bind analysis stage that included a placebo. The objective was to form that using LGD-4033 was harmless and easy to stomach with a dose not beyond 22 mg a day.
Clinical runs also showed that LGD-4033 has the ability to set off the following benefits when taken consistently:
An Increase In Strength Levels
Lean Muscle Mass Improved
A Drop In Body Fat
Has Healing Properties
Does Not Cause The Undesirable Side Effects Caused By Prohormones And Anabolic Steroids
LGD-4033, a novel nonsteroidal, oral selective androgen receptor modulator, binds to the androgen receptor with high affinity and selectivity. It demonstrates anabolic activity in muscles, anti-resorptive and anabolic activity in bones and a robust selectivity for muscle and bone versus prostate and sebaceous glands. LGD-4033 has recently completed a Phase I Multiple Ascending Dose study in healthy volunteers. This randomized, double-blind, placebo-controlled Phase I study established the safety and tolerability up to doses of 22 mg per day.
Based on some latest studies and experiments conducted, Ligandrol can enhance lean muscle mass and decrease body fat. Also, it can boost strength for better and more challenging training performance, recovery and overall health. Thus, it comes as no surprise that athletes and bodybuilders use LGD-4033 to help them be in their best selves.
LGD is still fairly new (3-5 years), but the results have been very similar in studies and logs. LGD-4033 has undergone several recent studies and trials to find the best and safest way to use it. From these trials, the results have shown increases in lean body mass and decreases in body fat. There is also a significant increase in strength, well being, as well as healing possibilities.
Suggested dosage is 5-10 mg a day for 8 weeks. A protein-rich diet is also necessary as well as higher caloric intake if you plan to beef up by 10 pounds or more.
LGD has shown the most ability of any SARM to put on size that could be considered a bulk. This will, of course, be dependent upon the diet used. Users that have experienced more than 10lb. increases, and have had a significant increase in calorie intake. The possibility of this type of size is present with LGD use. A recommend dosage for this type of goal would be 5-10 mg day for 8 weeks.
Use LGD-4033 with SARMS triple pack (GW-501516, S-4 and LGD-4033) to make it more effective as you are aiming to add more size while cutting fat. Suggested dosage is 3-5 mg a day for 8 weeks.
LGD can be used to cut as well. It will shine more-so if ran in conjunction with SARMS S-4 and Cardarine (GW-501516). This would be similar to a SARMS triple stack that is normally ran with Ostarine, except there is a possibility of more size being put on while cutting. A good dose for this method would be 3-5 mg a day for 8 weeks.
LGD-4033 is best used for recomping. Many users have said that they’ve observed a boost in lean body mass and fat loss. Using it together with other SARMS such as GW-501516 or Cardarine will give you a stronger and better recomp. Suggested dosage is 5-8 mg per day for 8 weeks.
LGD seems to shine with this method. Many have seen an increase in lean body mass and a decrease in body fat. LGD seems to work the best with this method. Ran in conjunction with other SARMS, like cardarine (GW-501516), will only increase the likelihood of a stronger recomp. Recommended doses for recomping would be 5-8 mg a day for 8 weeks.
Anabolicum (LGD-4033) carries a half-life of approximately 30 hours and is best taken once daily. 10mg per day is the most common dose with some going as high as 20mg per day with little to no complications. Anabolicum can be stacked with other SARMs such as Ostarine (MK 2866) or Cardarine (GW-50156).
The effects of Anabolicum can range from bulking and cutting to total body transformation. It is hard to compare the power of Anabolicum to various anabolic steroids due to SARM’s still being relatively new to the market, but the effects do appear to be strong. Off-season or bulking athletes can expect to gain significant strength and muscle mass with adequate calories. They will also find water retention cannot occur, meaning any weight gained will be that of lean muscle tissue.
For the dieting or cutting athlete, one of the primary concerns is protecting lean muscle mass. When you want to lose fat, you must burn more calories than you consume, and this can and will lead to muscle tissue loss without protective agents. Regardless of how genetically superior an individual is, some muscle tissue loss is unavoidable. By increasing anabolic activity, such as attaching a potent SARM to the body, muscle tissue can be preserved. This will result in a tighter, leaner, harder and more muscular physique. Some data, although rudimentary at this stage has shown the effects of Anabolicum may also, to a degree, promote fat loss.
Increases in muscular endurance are also reported, especially when stacked with other SARMs. It is unclear how much of an effect Anabolicum will have on endurance when used alone.
The side effects of Anabolicum appear to be minimal and often non-existent in many users. Unlike anabolic steroids that promote large amounts of androgenic activity, such related negative effects appear to be absent in most all cases. Side effects of Anabolicum are possible, but again very rare, making it one of the more desirable items in the performance enhancement arsenal.
Estrogenic: The side effects of Anabolicum do not include any of an estrogenic nature, making water retention, bloating, gynecomastia and high blood pressure associated with water retention impossible. LGD-4033 does not promote aromatization, the conversion of testosterone to estrogen. No anti-estrogens are needed with the use of this SARM.
Androgenic: Despite an attachment to the androgen receptors, the target area remains muscle and bone. Acne and hair loss cannot occur with this SARM. The side effects of Anabolicum should also not be concerning to the prostate; some activity in the prostate may exist, but should be insignificant. Virilization, the masculine traits often promoted in women due to the use of anabolic steroids should not occur with this SARM.
Cardiovascular: No negative effects on the cardiovascular system have been reported, such as negative effects on cholesterol or blood pressure.
Testosterone Suppression: Testosterone suppression is possible but should not be as significant as suppression related to anabolic steroid use. Some claim suppression is suppression regardless of the rate, but that’s simplistic at best. A man with natural testosterone levels of 650 ng/dl who is suppressed to 450 ng/dl, that is a far cry from 42 ng/dl. More importantly,
data has shown Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) will both remain at their current state. Some data has also shown slight decreases in Sex Hormone Binding Globulin (SHBG), which in turn may increase Free testosterone levels. However, a significant increase in Free testosterone is unlikely. Post Cycle Therapy (PCT) medications may or may not be needed depending on the individual, but some period of normalization is generally required.
Hepatotoxicity: Although taken orally, LGD-4033 is not toxic to the liver and should have no affect on liver enzymes. This product does not belong to the C17-alpha alkylated (C17-aa) or methylated class of medications.
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