Liothyronine sodium is a synthetic (man-made) version of one of the two hormones made by the thyroid gland, triiodothyronine. It is used for treating individuals who are hypothyroid (do not produce enough thyroid hormones). Thyroid hormones increase the metabolism (activity) of all cells in the body. In the fetus, newborn infant and child, thyroid hormones promote growth and development of tissues. In adults, thyroid hormones help to maintain the function of the brain, the use of food by the body, and body temperature. The FDA approved liothyronine in May 1956.
Liothyronine is used to treat hypothyroidism (low production of Sex hormones) in adults and children.Prolonged hypothyroidism can result in a condition called myxedema in which patients develop swollen lips, thickened nose, and unusual deposits of material in the skin that are dry and waxy.These deposits also may appear in body tissues other than the skin. Liothyronine also is used for suppressing production of thyroid stimulating hormone in patients with goiters and for testing.
Liothyronine therapy generally is well-tolerated. If symptoms occur, they usually occur because there are toxic (too high) levels of thyroid hormone (hyperthyroidism).
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Synonyms:(S)-2-AMINO-3-[4-(4-HYDROXY-3-IODOPHENOXY)-3,5-DIIODOPHENYL]PROPIONIC ACID SODIUM SALT;SODIUM (S)-2-AMINO-3-[4-(4-HYDROXY-3-IODOPHENOXY)-3,5-DIIODOPHENYL]PROPIONATE;T3 SODIUM SALT;T3, NA;O-[4-HYDROXY-3-IODOPHENYL]-3,5-DIIODO-L-TYROSINE SODIUM SALT;LIOTHYRONINE SODIUM;LIOTHYRONINE SODIUM SALT;H-THY(3,3',5-I3)-ONA
Product Categories:Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;Isolabel;Other APIs
Melting point 205 °C (dec.)(lit.)
alpha 20 º (c=2,alcohol/1.2N HCl)
storage temp. 2-8°C
solubility 4 M NH4OH in methanol: 125 g/5mL, clear, yellow-brown