Lorcaserin affects chemical signals in the brain that control appetite. Lorcaserin works by helping you feel full with smaller meals.
Lorcaserin is used together with diet and exercise to treat obesity.
Lorcaserin is sometimes used to treat obesity that may be related to diabetes, high cholesterol, or high blood pressure.
Lorcaserin will not treat any underlying health condition (such as heart disease, diabetes, high blood pressure). Keep taking any other medications your doctor has prescribed to treat these conditions.
Lorcaserin, currently marketed under the trade name Belviq and previously Lorqess during development, is a weight-loss drug developed by Arena Pharmaceuticals. It reduces appetite by activating a type of serotonin receptor known as the 5-HT2C receptor in a region of the brain called the hypothalamus, which is known to control appetite.
Lorcaserin is used to help adults who are obese or who are overweight and have weight-related medical problems to lose weight and keep from gaining back that weight. Lorcaserin must be used along with a reduced calorie diet and an exercise plan. Lorcaserin is in a class of medications called serotonin receptor agonists. It works by increasing feelings of fullness so that less food is eaten.
Lorcaserin is a selective 5-HT2C receptor agonist, and in vitro testing of the drug showed reasonable selectivity for 5-HT2C over other related targets. 5-HT2C receptors are located almost exclusively in the brain, and can be found in the choroid plexus, cortex, hippocampus, cerebellum, amygdala, thalamus, and hypothalamus. The activation of 5-HT2C receptors in the hypothalamus is supposed to activate proopiomelanocortin (POMC) production and consequently promote weight loss through satiety. This hypothesis is supported by clinical trials and other studies. While it is generally thought that 5-HT2C receptors help to regulate appetite as well as mood, and endocrine secretion, the exact mechanism of appetite regulation is not yet known. Lorcaserin has shown 100x selectivity for 5-HT2C versus the closely related 5-HT2B receptor, and 17x selectivity over the 5-HT2A receptor.
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
The regular tablet is usually taken 2 times per day. The extended-release tablet is taken only once per day. Follow your doctor's instructions.
Do not crush, chew, or break an extended-release tablet. Swallow it whole.
You may take lorcaserin with or without food.
You should lose at least 5% of your starting weight during the first 12 weeks of taking lorcaserin and eating a low calorie diet. Call your doctor if you do not lose at least 5% of your starting weight after taking the medicine for 12 weeks.
Lorcaserin is only part of a complete program of treatment that also includes diet, exercise, weight control, and possibly testing your blood sugar. Follow your diet, medication, and exercise routines very closely.
Store at room temperature away from moisture and heat.
Keep track of the amount of medicine used from each new bottle. Lorcaserin is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.
Do not share lorcaserin with another person. Keep the medication in a place where others cannot get to it.
Lorcaserin comes as a tablet to take by mouth. It is usually taken with or without food twice a day. Take lorcaserin at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lorcaserin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Lorcaserin may be habit forming. Do not take a larger dose, take it more often, or take it for a longer period of time than prescribed by your doctor.
If you do not lose a certain amount of weight during the first 12 weeks of your treatment, it is not likely that you will benefit from taking lorcaserin. Your doctor may tell you to stop taking lorcaserin if you do not lose enough weight during the first 12 weeks of your treatment.
Lorcaserin will help control your weight only if you continue to take it. Do not stop taking lorcaserin without talking to your doctor.
4. Dosage of raw Lorcaserin powder
Usual Adult Dose for Weight Loss:
10 mg orally twice per day
Comments: Response to therapy should be evaluated by week 12. If a patient has not lost at least 5% of baseline body weight, discontinue this drug as it is unlikely the patient will achieve and sustain clinically meaningful weight loss with continued treatment.
Use: Adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in patients with an initial body mass index (BMI) of 30 kg/m2 or greater (obese) OR 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbidity such as hypertension, type 2 diabetes mellitus, or dyslipidemia.
5. Warning of raw Lorcaserin powder
You should not use lorcaserin if you are allergic to it.
Do not use lorcaserin if you are pregnant. Weight loss during pregnancy can harm an unborn baby, even if you are overweight. Tell your doctor right away if you become pregnant during treatment.
To make sure lorcaserin is safe for you, tell your doctor if you have:
congestive heart failure;
a heart valve disorder;
a heart condition such as "AV block" (2nd or 3rd degree);
sickle cell anemia;
leukemia or myeloma;
kidney or liver disease; or
a physical deformity of the penis (such as Peyronie's disease).
It is not known whether lorcaserin passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
Lorcaserin is not approved for use by anyone younger than 18 years old.
tell your doctor and pharmacist if you are allergic to lorcaserin, any other medications, or any of the ingredients in lorcaserin tablets. Ask your pharmacist or check the patient information for a list of the ingredients.
tell your doctor and pharmacist what prescription and nonprescription medications and vitamins you are taking or plan to take. Be sure to mention any of the following: bupropion (Aplenzin, Forfivo, Wellbutrin, Zyban); cabergoline; codeine (in some pain medications and cough medications); dextromethorphan (in cough and cold medications); flecainide (Tambocor); insulin and other medications for diabetes; linezolid (Zyvox); lithium (Lithobid); medications for erectile dysfunction, or mental illness; medications for migraine headaches such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig); other medications for weight loss; metoprolol (Toprol); mexiletine; monoamine oxidase (MAO) inhibitors, including isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); odansetron (Zofran); propafenone (Rythmol); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine, paroxetine (Paxil), and sertraline (Zoloft); selective serotonin/norepinephrine reuptake inhibitors (SNRIs) such as duloxetine (Cymbalta) and venlafaxine (Effexor); tamoxifen (Soltamox); timolol (Blocadren); tricyclic antidepressants (TCAs) such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); and tramadol (Conzip, Ultram, Ryzolt). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with lorcaserin, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
tell your doctor what herbal products and nutritional supplements you are taking, especially St. John's wort, tryptophan, and herbs or supplements for weight loss.
tell your doctor if you have or have ever had blood cell problems such as sickle cell anemia (a disease of the red blood cells), multiple myeloma (cancer of the plasma cells), or leukemia (cancer of the white blood cells); a condition that affects the shape of the penis such as angulation, cavernosal fibrosis, or Peyronie's disease;diabetes; heart failure, slow or irregular heartbeat, or other heart problems; or liver or kidney disease.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking lorcaserin, call your doctor immediately. Lorcaserin may harm your unborn baby.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking lorcaserin.
you should know that lorcaserin may cause drowsiness and difficulty paying attention or remembering information. Do not drive a car or operate machinery until you know how this medication affects you.
6. What Are the Possible Side Effects of raw Lorcaserin powder?
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using lorcaserin and call your doctor at once if you have:
unusual changes in mood or behavior, thoughts of suicide or hurting yourself;
feelings of standing next to yourself or being outside of your body;
memory problems, trouble concentrating;
breast swelling (in women or men), nipple discharge;
penis erection that is painful or lasts longer than 4 hours;
heart problems--fast heart rate, trouble breathing, dizziness, ongoing weakness, or swelling in your arms, hands, legs, or feet;
high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting; or
severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.
Common side effects may include:
headache, dizziness, feeling tired;
dry mouth, cough;
back pain; or
low blood sugar (in people with diabetes).
In clinical trials, the most common side effect was headache, experienced by about 18% of drug arm participants compared to 11% of placebo participants. Headache was the only reported side effect to occur at a frequency greater than 5 percentage points above those from placebo. Other reported side effects and their rates for lorcaserin and placebo patients, respectively, were as follows: upper respiratory tract infection (14.8% vs. 11.9%), nasopharyngitis (13.4% vs. 12.0%), sinusitis (7.2% vs. 8.2%), and nausea (7.5% vs. 5.4%). Adverse events of depression, anxiety, and suicidal ideation were infrequent and were reported at a similar rate in each treatment group.
In December 2012, the US Drug Enforcement Administration proposed classifying lorcaserin as a Schedule IV drug because it has hallucinogenic properties at higher than approved doses and users could develop psychiatric dependencies on the drug. On 7 May 2013, the US Drug Enforcement Administration classified lorcaserin as a Schedule IV drug under the Controlled Substances Act.
There has been concern that lorcaserin can cause cardiac valvulopathy based upon the reports of subjects taking the drug in Phase 2 trials. However, a Phase 3 clinical trial of the drug was conducted and the results published in the October 2014 Postgraduate Medicine journal, a peer-reviewed medical journal for physicians. These results found no statistically significant differences in valvulopathy rates compared to control, being 2.4% for the drug subjects and 2.0% for controls.
Tell your doctor about all your current medicines and any you start or stop using, especially:
St. John's wort;
tryptophan (also called L-tryptophan);
any type of antidepressant;
cold or cough medicine that contains dextromethorphan (a cough suppressant);
erectile dysfunction medicine--avanafil, sildenafil, tadalafil, Cialis, Levitra, Viagra, and others;
medicine to treat mental illness, anxiety, or a mood disorder; or
a "triptan" migraine headache medicine--such as almotriptan, frovatriptan, rizatriptan, sumatriptan, zolmitriptan, Imitrex, Maxalt, Zomig, and others.
This list is not complete. Other drugs may interact with lorcaserin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
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