Mesterolone was synthesized and introduced for medical use in 1934 and was the first AAS to be marketed. It was followed by methyltestosterone in 1936 and testosterone propionate in 1937. The drug continues to be widely available and used today. Mesterolone is a synthetic and orally active anabolic–androgenic steroid (AAS) and a derivative of dihydrotestosterone (DHT).It is described as a relatively weak AAS and is rarely used for the purpose of androgen replacement therapy, but is still widely used. It is sold under the brand name Proviron among others.
Mesterolone is used in the treatment of androgen deficiency in male hypogonadism, anemia, and to support male fertility among other indications. it was used with some success in controlled studies of men suffering from various forms of depression. Mesterolone is a relatively weak androgen and rarely used for replacement therapies.
Mesterolone had seen widespread use in bodybuilding primarily for antiestrogenic activity in anabolic steroid stacks but such use has declined after introduction of aromatase inhibitors and SERMs. Most significant benefits of current Mesterolone use are considered by bodybuilders to be maintaining libido off-cycle and also relatively and temporarily improving vascularity.
During a bulking phase Proviron is not going to be a foundational steroid, and for most men it will not have a place in an off-season cycle. There are exceptions and we’ll go over those here. Adding in Proviron could possibly help the individual breakthrough a sticking point during his cycle. At some point and time in all cycles the progress begins to wane, and in some cases come to a complete halt. By the way Proviron enhances the total free state of the othersteroids being used in a stack, it could possibly help the individual breakthrough this sticking point.
During the off-season, this is where most will use the largest amount of testosterone. Many will use large amounts during cutting cycles too, especially competitive bodybuilders but lower testosterone plans are more common during the cutting phase. However, there are those for numerous reasons who choose to run off-season cycles with limited testosterone doses. In such plans, including Proviron could give them a slight needed androgen boost. While it may not always be necessary it could prove to be beneficial.
Mesterolone, also known as 1α-methyl-4,5α-dihydrotestosterone (1α-methyl-DHT) or as 1α-methyl-5α-androstan-17β-ol-3-one, is a synthetic androstane steroid and derivative of DHT.It is specifically DHT with a methyl group at the C1α position. Closely related AAS include metenolone and its esters metenolone acetate and metenolone enanthate. The antiandrogen rosterolone (17α-propylmesterolone) is also closely related to mesterolone
Like other AAS, mesterolone is an agonist of the androgen receptor (AR). It is not a substrate for 5α-reductase, as it is already 5α-reduced, and hence is not potentiated in so-called "androgenic" tissues such as the skin, hair follicles, and prostate gland. Mesterolone is described as a very poor anabolic agent due to inactivation by 3α-hydroxysteroid dehydrogenase (3α-HSD) in skeletal muscle tissue, similarly to DHT and mestanolone (17α-methyl-DHT). In contrast, testosterone is a very poor substrate for 3α-HSD, and so is not similarly inactivated in skeletal muscle. Because of its lack of potentiation by 5α-reductase in "androgenic" tissues and its inactivation by 3α-HSD in skeletal muscle, mesterolone is relatively low in both its androgenic potency and its anabolic potency. However, it does still show a greater ratio of anabolic activity to androgenic activity relative to testosterone.
Mesterolone is not a substrate for aromatase, and so cannot be converted into an estrogen. As such, it has no propensity for producing estrogenic side effects such as gynecomastia and fluid retention.It also has no progestogenic activity.
Because mesterolone is not 17α-alkylated, it has little or no potential for hepatotoxicity.However, its risk of deleterious effects on the cardiovascular system is comparable to that of several other oral AAS.
Mesterolone had seen widespread use in bodybuilding primarily for antiestrogenic activity in AAS stacks but such use has declined since the introduction of aromatase inhibitors and selective estrogen receptor modulators. Most significant benefits of current mesterolone use are considered by bodybuilders to be maintaining libido off-cycle and also relatively and temporarily improving vascularity.
Mesterolone is available widely throughout the world, including in the United Kingdom, Australia, and South Africa, as well as many non-English-speaking countries. It is not available in the United States, Canada, or New Zealand. The drug has never been marketed in the United States.
Proviron is a potentially powerful androgenic agent. Oftentimes, it is overlooked by many sportsmen. Nonetheless, it can actually makea significant contribution in order to achieve a lot in the world of bodybuilding. You only should use it properly. It is a pretty unique anabolic steroid and shares some similarities to Anavar, Masteron and some other popular brands. At first, it was used to treat androgen deficiencies. Nevertheless, it gained its fame thanks to a sufficient help in the gym.
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking mesterolone it is important that your doctor knows:
If you have liver or kidney problems.
If you have heart problems or high blood pressure.
If you have epilepsy or migraine.
If you have diabetes.
If you have cancer.
If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
If you have ever had an allergic reaction to a medicine
Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack.
Swallow the tablet whole with a drink of water. You can take mesterolone before or after meals.
Try to take your doses at the same times each day, as this will help you to remember to take them.
If you forget to take a dose, you should take it when you remember. However, if when you remember, it is nearly time for your next dose then leave out the forgotten dose. Do not take two doses at the same time to make up for a missed dose.
Proviron would hardly become a foundational steroid during a bulking cycle. It contains no anabolic properties. Accordingly, there would be little usefulness from its effects to build muscle mass. Nevertheless, it can go as a supplementary preparation for the main steroids. It increases the levels of bioavailable testosterone, which reaches the point of 90%. Therefore, it can provide an athlete with other benefits. A proper combination with other steroids may do well for most athletes so that they could gain more muscle mass.
It can greatly serve you while the middle of your cycle. There will be a stage when your body would not be able to progress and all of your results would be stagnant. Using this steroid when it is needed may help you to continue the gains.
Conventionally, athletes use Proviron during a cutting phase when it is most effective and beneficial. It provides a strong hardening effect. The product ensures a great fat burning option. The binding to the androgen receptor provides a dependable melting of fats.
Simultaneously, it protects the body from muscle loss. This is the most valuable trait of this steroid. In addition, it causes almost no water retention, which a tremendous advantage in comparison to other similar anabolic steroids. An enhanced androgenicity easily provides these options.
There is one more peculiarity about this preparation. It can improve libido. Its influence is pretty soft, but it ensures a high condition of libido. Thanks to anti-estrogen property, it isn't an issue for gynecomastia.
The dosing of the product is individual. You should pick up the safest and most efficacious dose.
The half life of proviron is around 12 hours. A good recommended dosage is 25-75mg per day; though, The detection time is 5-6 weeks. so those that are tested often would be wise to avoid this compound. Females are not advised to take proviron because of its DHT properties. Side effects for females can be very nasty and unpredictable.
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
If you are having an operation or dental treatment tell the person carrying out the treatment which medicines you are taking.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you are about to be started on any new medicine, remind your doctor and pharmacist that you are taking Proviron.
Tell any other doctors, dentists, and pharmacists who treat you that you are taking this medicine.
If you are going to have surgery, tell the surgeon or anaesthetist that you are taking this medicine.
It may affect other medicines used during surgery.
Keep all of your doctor’s appointments so that your progress can be checked.
Your doctor may do some tests (such as blood tests and regular examinations of the prostate) from time to time to make sure the medicine is working and to check for unwanted side effects.
If you experience prolonged stomach pain, blood in the stools or vomit, or yellowing of the skins and eyes during treatment with Proviron, tell your doctor immediately
There have been cases reported of patients developing liver tumours while taking Proviron. Your doctor may tell you to stop using Proviron.
Things you must not do
Do not take Proviron to treat any other complaints unless your doctor tells you to.
Do not give your Proviron tablets to anyone else, even if they have the same condition as you.
Do not stop taking your medicine or lower the dosage without checking with your doctor.
If you stop taking it suddenly, your condition may worsen or you may have unwanted side effects.
Since proviron is such a pure DHT derivative, we can logically say that it comes with sides, just like any other anabolic steroid. However, the side effects come from its DHT characteristics, so you can expect male pattern baldness issues, especially if you are prone to it. This is why those that choose DHT compounds and suffer from hair issues will run a 5alpha reductase inhibitor such as finasteride, or dutasteride, to counteract this side effect. DHT's can also enlarge the prostate, but this is generally only in those that abuse them. As mentioned above, proviron is not a c17 alpha-alkylated compound, so liver problems are not an issue with it.
Possible mesterolone side effects:
-Headache and other aches and pains
Advice: Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the pain does not ease, speak with your doctor
-Feeling sick (nausea), tummy (abdominal) pain
Advice: Stick to simple foods - avoid rich or spicy meals. If the pain does not ease quickly, speak with your doctor straightaway
-Acne, swollen hands or feet, raised blood pressure, increased body hair, breast or prostate problems, increased weight, baldness, mood changes
Advice: If any of these become troublesome, let your doctor know.
if you experience frequent erections or erections that last for a long time, you must let your doctor know about this. Your treatment will need to be reviewed in order to prevent any injury.
If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.
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