Enobosarm, better known as as Ostarine or MK 2866, is a Selective Androgen Receptor Modulator (SARM) developed by GTx (GTx-024) to combat muscle wasting and osteoporosis. Many speculate Ostarine may find uses in hormone replacement treatment plans, as well as in the treatment of sarcopenia, cachexia and muscle atrophy. This is a highly valuable benefit to those suffering from muscle wasting diseases, more so because SARM’s have been shown to not have an impact on non-skeletal muscle.
Ostarine, also known as MK-2866 is a SARM (selective androgen receptor module) created by GTx to avoid and treat muscle wasting. It can later on be a cure for avoiding atrophy (total wasting away of a body part), cachexia, sarcopenia and Hormone or Testosterone Replacement Therapy.
This type of SARM cannot only retain lean body mass but as well as increase it. Ostarine is often mistaken as S1 but S1 was created earlier and is no longer going through more expansion.
As a SARM, Ostarine binds directly to the androgen receptors. While anabolic steroids also bind to androgen receptors, SARM’s cannot convert to DHT or estrogen. Officially belonging to a group of drugs, Ligand, MK 2866’s only purpose is direct anabolic activity. This SARM can be used for muscle growth or muscle preservation (diet dependent).
Test 600x Ostarine, like anabolic steroids, will increase protein synthesis as well as nitrogen retention. However, unlike anabolic steroids, it will do so without any DHT (dihydrotestosterone) or estrogen conversion. While no direct estrogen conversion is present in terms of aromatase activity,
mild increases in estrogen levels have been shown. This is perhaps why Ostarine has been shown to be good for joint health and healing. Estrogen often gets a bad wrap, but some is needed for good health and physical performance. It is, however, the direct binding to the receptor that is most important as it not only promotes anabolism, it alters the gene sequence directly at the receptor site; in fact, it is highly tissue specific, muscle and bone.
MK 2866 carries a half-life of approximately 24 hours.
SARMS bind to the androgen receptor (AR) and shows osteo (bone) and myo (muscular) selective anabolic activity. The tying and stimulation intensifies protein synthesis and builds muscle.
Ostarine causes muscle growth just like steroids but it won’t produce negative side effects commonly found in anabolic steroids and prohormones such as prostate and other secondary sexual organs.
MK-2866 uses its anabolic effects on muscle tissue fully so it’s not only a potential for curing muscle wasting ailments but also it has great potential for muscle building for athletes, bodybuilders and fitness buffs. It is also an agent to reduce degeneration during recovery times from serious surgery or similar conditions.
*Ostarine has undergone 8 scientific trials by GTx with about 600 subjects plus 3 efficiency studies. A 4-month Phase IIb medical trial including 159 patients have shown a complete boost in total lean muscle mass compared to placebo and the secondary goal of increasing muscle strength.
In terms of bodybuilding, Ostarine users have proven that MK-2866 can help improve lean muscle mass and strength levels.
Shines best when used for gaining lean muscle (bulking) as it is the most anabolic of all the SARMS. Suggested dosage is 25 mg for 4-6 weeks. PCT is not necessary. An increase of 6 lbs. of lean, keepable gains can be observed during this period.
You can take Ostarine as high as 36 mg for 8 weeks BUT only if you weigh 210 lbs. Suppression is expected in higher doses so PCT after a cycle is a must.
Ostarine shines in recomping due to its nutrient portioning results. Calorie is used to build muscle which helps in weight loss and enhancing muscle mass and strength. Suggested dosing is 12.5-25 mg for 4-8 weeks.
*Your diet must contain 30% of lean sources of protein to achieve the best recomp result.
MK-2866 can help cut whilst preserving muscle gains and decreasing calories. Suggested dosing is 12.5-15 mg for 4-6 weeks.
Ostarine for Preventing Injuries
The effects of MK-2866 convert to anabolism in bone and skeletal muscle tissue, which means it could be used in the future for different purposes such as osteoporosis and as a simultaneous treatment with drugs that decrease bone density. So, it has great use as a compound for injury recovery, specifically bone and tendon related injuries.
Suggested dosage is 12.5 mg a day.
MK 2866 is an orally administered SARM. For the purposes of muscle preservation when dieting, a minimum of 15mg per day is normally taking. For growth to be spurred, most users will find 20-25mg per day to be a good place to start. Some heavier individuals may find 30mg per day to be needed, but most data shows such doses often make little difference compared to the 20-25mg ranges in most men.
Total use will normally last 6-8 weeks with 4 weeks of no SARM use once a cycle of Ostarine is complete. Although testosterone suppression may not be heavy, PCT may or may not be needed. However, some suppression will exist and it’s best to give the body a chance to normalize. MK 2866 carries a half-life of approximately 24 hours; once daily dosing is sufficient. There is no advantage to multiple doses per day.
Ostarine can be used for gaining as well as preserving muscle mass. For the athlete, this means it can be used in both cutting and bulking phases. The user can expect significant gains in lean body mass without unwanted water retention or fear of gynecomastia often associated with anabolic steroids.
The individual will unlikely gain as much weight as he would from a cycle of Dianabol or Anadrol; however, the gains will be cleaner and easier to maintain post use. It is very common for the individual to associate all weight gain with positive gains when using certain steroids, but lean muscle gains are the only ones that count.
Ostarine can also be very useful during the cutting or dieting phase. This may be the best time to use the SARM for its muscle protecting qualities. In order to lose body fat, you must burn more calories than you consume. Being in a calorie deficit puts lean muscle mass at risk, some loss will occur. If we can protect our muscle mass during a diet, we not only look better we actually continue to burn fat.
A loss of muscle mass will hinder the metabolism making fat loss difficult. Protect the muscle mass and you protect the metabolism. Ostarine will also offer up significant joint healing and repair, which is invaluable when dieting. Harsh or hard dieting can often lead to joint discomfort. If we can protect our joints, as well as increase tendon and ligament strength, collagen synthesis and enhance bone mineral content, we can continue to train and train harder.
The effects of MK 2866 in this manner are truly beneficial in a bulking or cutting phase, but they will typically stand out more during the cutting phase. The effects of Ostarine in this regard are so strong data has shown it may directly treat injuries, and not a masking scenario as with pain meds but actual healing of joints, ligaments, tendons and bone.
MK-2866 can give you:
Increased Lean Mass Gains
Joint Healing Abilities
Anabolic (Even At Doses As Low As 3 Mg)
The side effects of Ostarine are limited as it appears to be a relatively side effect friendly drug. Many of the adverse effects associated with anabolic steroids will not exist with this SARM; however, some will, although mildly.
Estrogenic: The side effects of Ostarine should not include those of an estrogenic nature as the SARM does not aromatize. There is no conversion of testosterone to estrogen associated with this drug. Water retention, bloating, gynecomastia or high blood pressure due to water retention cannot occur. However, data shows that some increases in existing estrogen may occur, but should be very mild and not enough to warrant the use of an anti-estrogen. If this very slight increase is concerning, if an anti-estrogen is used, you may easily bottom out your estrogen levels, which can lead to numerous hormone imbalances and related effects.
Androgenic: Androgenic side effects of Ostarine, despite directly affecting the androgen receptor should not exist. This compound does not convert to DHT; acne and hair loss cannot occur. Androgenic side effects associated with virilization in women are also impossible. As there is no direct androgenic activity related to DHT, prostate issues should also be non-existent.
Cardiovascular: The side effects of Ostarine should present minimal cardiovascular risk. Both HDL and LDL levels may be reduced, but all data shows minimal to insignificant reductions.
Testosterone Suppression: It’s often said SARM’s will not suppress natural testosterone production, and it’s true they will not compared to anabolic steroids. However, some suppression is possible, but complete suppression is not. A testosterone-boosting supplement may be warranted while using MK 2866. Post Cycle Therapy (PCT) data is somewhat inconclusive as to if this is needed. Some men seem to experience greater levels of testosterone suppression than others.
Hepatotoxicity: Although orally administered, the side effects of Ostarine do not include liver toxicity. MK 2866 does not belong to the C17-alpha alkylated (C17-aa) class of drugs like many oral anabolic steroids. It does not mirror the MI metabolite associated with the SARM S4 that gives that particular SARM some hepatic activity.
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