Oxandrolone, is a 17α-methylated derivative of dihydrotestosterone (DHT) that has an oxygen atom in place of the carbon at the 2 position. is an orally active anabolic-androgenic steroid which first became available as a prescription drug in the United States in 1964.
The original brand name of oxandrolone was Anavar, which was marketed in the United States and the Netherlands.This product was eventually discontinued and replaced in the United States with a new product named Oxandrin, which is the sole remaining brand name for oxandrolone in the United States.Oxandrolone has also been sold under the brand names Antitriol (Spain), Anatrophill (France), Lipidex (Brazil), Lonavar (Argentina, Australia, Italy), Protivar, and Vasorome (Japan) among others.Additional brand names exist for products that are manufactured for the steroid black market.Among those using oxandrolone for non-medical purposes, it is often referred to colloquially as "Var", a shortened form of the brand name Anavar. Oxandrolone/Anavar represents one of the most popular oral anabolic steroids of all time, and this is largely due to its well-tolerated nature. This is one of the few anabolic steroids that can be used safely by men and women, and it’s also one of the most side effect friendly. However, in some circles Anavar is greatly underappreciated due to its mild nature, but this is generally due to unrealistic expectations.
Many tend to assume all anabolic steroids should yield a set of specific effects at a specific rate of power, but reality tells us varying steroids carry varying results and purposes. Anavar is without question an extremely beneficial anabolic steroid, but in order to appreciate its benefits we must understand it. Anavar is the popular brand name associated with the dihydrotestosterone derived anabolic steroid Oxandrolone.
The Oxandrolone hormone was first released in the early 1960’s under the trade name Anavar by G.D Searle & co. and was touted as carrying numerous therapeutic qualities. However, in 1989 Searle would discontinue the compound; this was largely due to FDA pressure that had tightened its grip on the anabolic steroid market. An important note; Searle also owned the licensing rights to the majority of Oxandrolone products on the global market, which would lead to this steroid nearly disappearing at this time. In 1995 the Oxandrolone hormone would reappear thanks to Bio-Technology General CORP (BTG),
now Savient, under the trade name Oxandrin. BTG would hold a monopoly on the product during this time driving its cost through the roof. Thankfully, a few U.S. based pharmacies such as Watson would begin manufacturing generic Oxandrolone in recent years driving the cost down. However, it remains one of the more expensive anabolic steroids on the market, including when purchased from most underground labs. An important note for future purchase; while Anavar remains the common associated name for the Oxandrolone hormone, the Anavar name itself is not used by any human grade pharmaceutical company that manufactures Oxandrolone.
Oxandrolone is use to treat a wide variety of disorders, these include idiopathic short stature, Turner syndrome, body mass loss from catabolic illness or long-term corticosteroid treatment, severe burns, surgical or general trauma, osteoporosis, anemia, hereditary angioedema, HIV/AIDS-induced wasting, alcoholic hepatitis, and hypogonadism. Some bodybuilders also use Oxandrolone for its muscle-building properties. Oxandrolone is well-established as a safe treatment for people recovering from severe burns. Medical research has also established oxandrolone's efficacy in aiding the development of girls with Turner syndrome. Although oxandrolone has long been used to accelerate growth in children with idiopathic short stature, it is unlikely to increase adult height, and in some cases may even decrease it. Oxandrolone has, therefore, largely been replaced by growth hormone for this use. Oxandrolone has been researched and prescribed as a treatment for a wide variety of conditions. It is FDA-approved for treating osteoporosis, aiding weight gain, and counteracting the catabolic effect of long-term corticosteroid treatment. As of 2016, it is often prescribed off-label to quicken recovery from severe burns, aid the development of girls with Turner syndrome, and counteract HIV/AIDS-induced wasting.
Oxandrolone/Anavar is usually given for only a few weeks, do not take this medicine in larger or smaller amounts or for longer than recommended. Oxandrolone oral tablets contain 2.5 mg or 10 mg of the anabolic steroid Oxandrolone. Take this medication by mouth usually 2 to 4 times daily or as directed by your doctor. It may be taken with food or milk if stomach upset occurs. Dosage is based on your medical condition and response to treatment.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. This medication is usually used for short-term treatment only. Misuse or abuse of an anabolic steroid can cause serious side effects such as heart disease (including heart attack), stroke, liver disease, mental/mood problems, abnormal drug-seeking behavior, or improper bone growth (in adolescents). Do not increase your dose or use this drug more often or for longer than prescribed. When an anabolic steroid is misused or abused, you may have withdrawal symptoms (such as depression, irritability, tiredness) when you suddenly stop using the drug. These symptoms may last from weeks to months.
Oxandrolone/Anavar has often been called a weak steroid. Part of the reason for this is that use of a Class I steroid alone never is maximally effective. The other cause is that bodybuilders and authors in the field sometimes make unfortunate and unreasonable comparisons when judging anabolic steroids. If say 8 tablets per day does little, then a drug is pronounced useless or weak. And traditionally, oxandrolone was available in 2.5 mg Anavar tablets, proving only 20 mg daily with such usage, which totals to only 140 mg/week. For comparison, testosterone at that dose also gives little results. Indeed, few anabolic steroids give dramatic results at that dose, but they are not called weak on that account. The proper conclusion is that such Anavar tablets were individually weak, but not that the drug lacks potency.
Anavar does not aromatize or convert to DHT, and has an 8 hour half-life. Thus, a moderate dose taken in the morning is largely out of the system by night, yet supplies reasonable levels of androgen during the day and early evening.
One study found oxandrolone to be superior to testosterone and to Deca (nandrolone) for reducing abdominal fat in men, or at least in obese older men at the specific low doses studied, which were not necessarily equipotent. From this, some have made broad generalizations to bodybuilding. However, this does not necessarily carry over to anabolic steroid cycles at doses commonly used in bodybuilding. In the case of the study in question, I expect the difference in outcomes was dose-related.
In practice, at total androgen doses typically used, one can cut just as effectively without oxandrolone as with, given any of various possible substitutions for the oxandrolone. This is not to say this drug is ineffective, but rather that other androgens including testosterone are also effective at high dose for abdominal fat loss..
Oxandrolone is indicated as adjunctive therapy to offset the protein catabolism associated with prolonged administration of corticosteroids, and for the relief of the bone pain frequently accompanying osteoporosis, Dosage is based on your medical condition and response to treatment. 5-10mg per day range with 20mg per day normally being the maximum dose,
Such use will normally last 2-4weeks with a small break after use before implementing the next 2-4week cycle.
For the male performance enhancing athlete, 20-30mg per day dosing will provide athletic enhancement, but most will find 40-50mg/day to be far more efficient. 80mg/day is not uncommon, but this will increase the risk of side effects.
In the case of low-dose use however, I do think it is a correct conclusion that for most, low dose Anavar use is more effective for cutting than equal dosages of most other anabolic steroids. This may be partly or entirely from additive effect with natural testosterone: such oxandrolone use may not suppress such its production, the user may enjoy both the full effect of his natural testosterone and the effect of the oxandrolone. In contrast, low-dose testosterone or nandrolone use results in substantial suppression of natural testosterone, and so there is less total effect.
If you are allergic to it, or if you have the following symptoms, you should not useOxandrolone/Anavar:
-advanced kidney disease,
-breast cancer(in men or in women who have hypercalcemia)
-if you are pregnant
-high levels of calcium in your blood(hypercalcemia)
- Pregnancy, because of possible masculinization of the fetus. Oxandrolone has been shown to cause embryotoxicity, fetotoxicity, infertility, and masculinization of female animal offspring when given in doses 9 times the human dose.
Like other AAS, oxandrolone may worsen hypercalcemia by increasing osteolytic bone resorption. When taken by pregnant women, oxandrolone may have unintended effects such as masculinization on the fetus. Oxandrolone greatly increases warfarin's blood-thinning effect, sometimes dangerously so.In April 2004, Savient Pharmaceuticals published a safety alert through the FDA warning healthcare professionals of this.Oxandrolone can also inhibit the metabolism of oral hypoglycemic agents.It may worsen edema when taken alongside corticosteroids or adrenocorticotropic hormone.
Anabolic steroids are synthetic derivatives of testosterone. Certain clinical effects and adverse reactions demonstrate the androgenic properties of this class of drugs. Complete dissociation of anabolic and androgenic effects has not been achieved. The actions of anabolic steroids are therefore similar to those of male sex hormones with the possibility of causing serious disturbances of growth and sexual development if given to young children. Anabolic steroids suppress the gonadotropic functions of the pituitary and may exert a direct effect upon the testes.
Women should be observed for signs of virilization (deepening of the voice, hirsutism, acne, clitoromegaly). Discontinuation of drug therapy at the time of evidence of mild virilism is necessary to prevent irreversible virilization. Some virilizing changes in women are irreversible even after prompt discontinuance of therapy and are not prevented by concomitant use of estrogens. Menstrual irregularities may also occur.
Cholestatic hepatitis and jaundice may occur with 17-alpha-alkylated androgens at a relatively low dose. If cholestatic hepatitis with jaundice appears or if liver function tests become abnormal, Oxandrolone should be discontinued and the etiology should be determined. Drug-induced jaundice is reversible when the medication is discontinued.
In children, androgen therapy may accelerate bone maturation without producing compensatory gain in linear growth. This adverse effect results in compromised adult height. The younger the child, the greater the risk of compromising final mature height. The effect on bone maturation should be monitored by assessing bone age of the left wrist and hand every 6 months
Almost complete absence of side effects makes Oxandrolone one of the most safe steroids. It is not aromatized and in any dosage does not affect the production of endogenous testosterone.
The common seen side effect of Oxandrolone is: Nausea, vomiting, headache, skin color changes, increased/decreased sexual interest, oily skin, hair loss, and acne. Known or suspected carcinoma of the prostate or the male breast.
Carcinoma of the breast in females with hypercalcemia (androgenic anabolic steroids may stimulate osteolytic bone resorption).Pregnancy, because of possible masculinization of the fetus. Oxandrolone has been shown to cause embryotoxicity, fetotoxicity, infertility, and masculinization of female animal offspring when given in doses 9 times the human dose. Nephrosis, the nephrotic phase of nephritis. Hypercalcemia. Another possible side effect is diarrhea. However, this effect was observed in a very small number of athletes, and only at high doses.
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