Phenylpiracetam (Phenotropil) is a nootropic of the racetam family(smart drug), and as its name suggests it is a phenyl- derivative of piracetam. Phenylpiracetam is reported to be more neuroprotective than piracetam is, but also possesses psychostimulatory properties and is reported to enhance physical performance.
There is a fair bit of research to suggest that phenylpiracetam is effective, like other racetam drugs, in attenuating the rate of and symptoms of cognitive decline. Many of these studies use phenylpiracetam for over one month's time, and the benefits seen may only apply to organic causes of cognitive decline (dementia and stroke) rather than traumatic brain injury.
Phenylpiracetam is a lesser-known member of the racetam family of nootropics but has seen an increase in popularity over the past couple of years. Not only is phenylpiracetam a powerful cognitive enhancer, it is also unique in its ability to boost athletic performance.
Phenylpiracetam is one of the most potent nootropics that are available on the market today. It is a relatively new nootropic from the racetam family and is a modified version of the original nootropic piracetam, except it is estimated to be 30 to 60 times more powerful, have better neuroprotective properties, and enhances physical performance. For all these reasons, phenylpiracetam is rapidly gaining prevalence among nootropic users.
Structurally, phenylpiracetam is essentially piracetam with a phenyl group attached to it. That makes it quite similar to piracetam, its parent molecule, but the addition of the phenyl group improves it in the following two ways:
More Potent – Increased potency and stronger effects by allowing the molecule to pass the brain-blood barrier (BBB) easier.
Energizing – More stimulating effects due to a closer resemblance to a phenethylamine substance, such as Adderall.
In comparison to other racetams, phenylpiracetam is quite potent and has a high bioavailability even when ingested orally. Its half-life is around 3-5 hours in humans.
Phenylpiracetam’s energy boosting properties likely exist due to its close resemblance those of phenylethylamine, an organic compound which is known for its stimulatory effects. The benzene ring of the phenyl group likely also increases the affinity for neurotransmitter (norepinephrine and dopamine) transporters.
Phenylpiracetam is quickly gaining popularity with nootropic users for its powerful effects. Consider trying it out as an interesting alternative to the more common racetams. As always, it is recommended to start out by taking a low dosage, without other nootropics, to gauge your sensitivity to it.
Phenylpiracetam is a drug so powerfully stimulating, the Olympic committee has banned its use for athletes competing at this high level. While it is not legally banned or inherently dangerous, this should tell you something about the efficacy of phenylpiracetam for enhancing feelings of stimulation. What’s the true power of phenylpiracetam?
A lack of scientific research stymies any strong recommendation of phenylpiracetam, but the evidence that does exist looks promising. One study showed phenylpiracetam is a cognitive enhancer to improve with general cognition and learning. Beyond learning and memory, which is common amongst the racetam family, there are benefits as an antidepressant as well. Studies showed that using phenylpiracetam can reduce symptoms of depression.
What phenylpiracetam lacks in statistics, data, and research, it makes up for in anecdotal evidence. This nootropic compound is among the most stimulating of racetams, which makes it both a great focus and concentration tool as well as a memory and learning enhancer.
Phenylpiracetam is taken at a dosage of 100-200mg acutely, and this dose is taken 2-3 times per day (totalling a daily range of 200-600mg). The lower range seems effective, but the optimal dosage is not yet known.
The R-isomer appears to be more active on the common usages of phenylpiracetam (stimulation and cognition) than does the S-isomer, and while the racemic mixture (commonly sold version) is effective for cognitive decline it is not certain if it works for nootropic purposes in youth.
Tolerance to phenylpiracetam is reported to develop relatively quickly. Therefore, it is not advised to take it as a daily supplement but instead as a tool to augment your abilities when you need it the most or to cycle it periodically.
Like other nootropics in the racetam class, there are few reported side effects from supplementing phenylpiracetam when taken at the recommended dosages. If you do experience headaches, it may be a sign that you should add or increase your choline supplementation, which is usually recommended when taking racetams.
Any nootropic, especially one that is stimulating, has the potential for side effects. The phenylpiracetam studies on sleep and psychostimulation prove one of the main problems can be insomnia. People who take phenylpiracetam too late in the evening or afternoon might be unable to get quality sleep due these effects.
Additionally, standard racetam side effects also apply to users of phenylpiracetam. Some people struggle with a headache due to a lack of acetylcholine (remedied by alpha GPC or citicoline). Other people have phenylpiracetam side effects such as overstimulation or jitteriness, nausea, or irritability.
When a user experiences phenylpiracetam side effects similar to overstimulation or irritability, it may be a sign to reduce the phenylpiracetam dosage rather than quit outright. Some public figures, such as Dave Asprey, have popularized this drug but at a high dose (he has recounted consuming 500 mg). This is considerably higher than the recommended starting dose and it would be common to experience phenylpiracetam side effects as you will read below.
Phenylpiracetam increases memory and overall cognition more effectively than piracetam, protects the brain, and has been reported to enhance physical performance.
Phenylpiracetam is a great addition to any nootropic stack due to its effects and potent nature. Specifically, athletes and students may benefit the most due to its stimulating and motivating properties. Not to mention, it provides an increased tolerance to stress which is a valuable bonus.
Phenylpiracetam has even been given to Russian soldiers and astronauts for its ability to enhance the performance of both the mind and body.
In studies, phenylpiracetam has shown the following effects.
Improve memory, attention-switching, and problem-solving skills in patients with asthenia.
Increase locomotor and antidepressant activity and improve memory in rats.
Shown to prevent and reduce the effects of Amnesia.
Ability to suppress the anxiety and fear response in rats with induced immune stress.
Reported to reduce the effects of sleep deprivation for the duration of its effects by many users.
Reduces the effects of cold on our body by increasing one’s tolerance to it.For Studying and Learning.
The benefits of phenylpiracetam are especially useful for studying and learning. Its stimulating nature is great for an otherwise sleep deprived cram session, pretest focus aid, or just a general cognitive study enhancer. Its effects on memory allow for complete retention enhancement. Motivation and mood enhancement allow for general better study as well. Finally, its ability to reduce the effects of stress and anxiety should allow for better studying under pressure.
Phenylpiracetam is also great for working out and enhancing athletic performance. It reduces the negative effects of stress on your body, which is invaluable for an athlete, increasing stamina, recovery, and endurance. This increased tolerance to stress also includes increasing your body’s tolerance to cold.
Phenylpiracetam also provides an energy similar to that of an amphetamine. Clean, focused, motivated energy without caffeine jitters is ideal in a compound to help optimize your performance during workouts or competitions. There also is little to no crash, even when compared to caffeine.
Professional athletes should note that phenylpiracetam is on the World Anti-Doping’s banned substance list and should decide on phenylpiracetam supplementation accordingly.
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