Testolone (RAD140) is the newest compound in the family of selective androgen receptor modulators, or as they are better known – SARMS. Therefore, its major advantage over anabolic steroids is that it offers similar positive results, with barely any side effects at all. Indeed, this is quite a unique compound, even when it is compared to other SARMS.
In the studies involving RAD140, also known as Testolone, testing was carried out mostly on mice and monkeys. However, the results of these studies have shown to be very promising. For instance, it was proven that RAD140 has the unique property of countering the prostate-enlargement caused by testosterone use, which makes it a perfect stacking agent for highly androgenic steroids that can cause this undesired effect.
Furthermore, when Testolone was given to monkeys, there was a drastic increase in lean bodyweight during the administration period. This increase in lean mass was dosage dependent, so with bigger dosages there was a more pronounced increase in lean mass and loss of fat tissues. Hence, testolone is a true SARM with all the properties that are expected from compounds of this kind - safety and effectiveness.
Of the currently available SARMs, RAD 140 is the most recently developed. If you are new to the world of SARMs, you may have realized that many tend to have unusual names consisting of a series of letters and numbers. These research chemicals have not been approved for official use in the medical field. This is why they are still being identified by abbreviations of their respective developers’ names. RAD 140 is currently being developed by a company called Radius Health, which explains the “RAD” portion of the name. Many of these compounds also have unofficial names that sound similar to the names of steroids – for instance, just as RAD 140 is also known as testolone, LGD-4033 is known as ligandrol.
Non-steroidal SARMs have been around for decades (and steroidal SARMs even longer). This supplement was announced to the research world in 2010, making it extremely new compared to some of the considerably older SARMs. Because of its general newness, there are far fewer studies on it than have been done on older SARMs, like the popular ostarine. Ostarine and older SARMs have been tested somewhat extensively on humans. Most RAD 140 studies have been done on animals, but the results are still promising. Further animal research is likely to lead to clinical studies in humans, which in turn will provide the bodybuilding community with valuable information concerning dosage and other variables.
While much of the general research on SARMs focuses on their mechanism of action and on their effects as a whole, experienced SARM users have noted that different SARMs have slight benefits in certain areas. For instance, ostarine is generally known as being especially useful as a cutting and recomp drug. Ligandrol (also called LGD 4033) is well-suited to bulking.
There is less of a general consensus on RAD 140, simply because this is such a new supplement. But with a 90:1 anabolic to androgenic ratio, it has the potential to create muscle growth similar to testosterone. Some users have noted that RAD 140 seems to improve speed and endurance as well. This supplement shows potential as an all-around performance enhancer as well as potential for building muscle.
Just like the rest of the SARMS, testolone has a selective mode of action, which allows it to have anabolic effects without the side effects usually seen with anabolic androgenic steroids (AAS). These side effects include prostate enlargement, suppression of natural testosterone production, head hair loss, and many others.
This means that RAD140 interacts almost exclusively with the androgenic receptors in the muscle tissues and bones, but it does not activate these receptors in other parts of the body. As a result, we get pronounced anabolic effects, but without side effects and suppression, which opens new possibilities for medical applications of this compound instead of testosterone. What's more, due to the selective mode of action, RAD140 is safe for females too, since it will not cause virilization, or clitoris enlargement.
Because it is part of the class of selective androgen receptor modulators, RAD 140 works similarly to most SARMs. Like other compounds in this class, RAD 140 interacts with androgen receptors, but it interacts almost exclusively with the receptors in muscle and bone. Research has confirmed that SARMs, including RAD 140, act in a tissue-selective way.
However, the exact mechanism of that tissue specificity is not well understood. Current research suggests that when the SARM binds to androgen receptors, it changes the receptor shape, which in turn helps create the anabolic effects that SARMs are known for.
This general idea of how testolone and other SARMs work explains the name “selective androgen receptor modulator.” This class of compounds is selective (because it targets only the androgen receptors in muscle and bone), and it causes receptor modulation (because it appears to alter the shape of the androgen receptor once it’s bonded to it).
Testolone, because of its influence on androgen receptors, can also increase a user’s response to training. This means that if you use an identical training and diet regimen without testolone and then use the same regimen with it, the testolone will amplify your results. All other things being equal, you’ll see more form your diet and training when you pair it with a well-thought out cycle of this supplement.
Understandably, most recreational bodybuilders focus on the muscle-building potential of testolone when looking at how it can help them improve their physiques. However, like other compounds in this class, testolone can also improve the strength of tendons and ligaments. For anyone who strength trains, this is a valuable effect. As bodybuilders make gains in muscular size and strength, it is vital that the tendons and ligaments also gain strength. Anyone who has suffered a tendon or ligament injury knows that healing can be a lengthy process. It also can lead to permanent damage and can severely hinder training.
Testolone, like most other SARMs, also decreases bone resorption. This means that it slows the breakdown of bone, which may increase bone density over time. In fact, many of the clinical studies of SARMs have focused on their potential uses in treating osteoporosis. In bodybuilding, this offers the benefit of reducing fracture risk. Fractures are not necessarily a common bodybuilding injury. But as with ligament and tendon injuries, a fracture has the potential to set back training considerably. There are also benefits for endurance athletes. For those who do a significant amount of high-impact cardio, intelligent supplementation may reduce the risk of stress fractures from overuse.
RAD 140 has several benefits in terms of boosting speed and power. At first glance, it may seem as though this doesn’t matter for bodybuilding. But an increase in energy and endurance can help support increased training intensity. This is helpful for those who are training on reduced calories during a cut. Testolone can help users maintain existing muscle mass while cutting as well. The combination of these effects makes it ideal for a bodybuilder in a cutting phase.
This supplement’s ability to support explosive power output also has potential for bodybuilders. It is generally well understood that high-intensity interval training, or HIIT, leads to the loss of more fat in less time when compared to steady-state cardio. HIIT training relies on bursts of power. It also may preserve existing muscle more effectively than steady-state training. Thus, testolone’s ability to support explosive power may improve the quality of HIIT training, leading to improved fat loss and better preservation of muscle.
Of course, explosive power is also vital to strength training itself. Whether you need to push past the sticking point on your bench press or are working to get that final rep on your last set of OHPs, having the reserve energy to use explosive power when you need it is invaluable when you want to train as hard as you possibly can.
While its effects have the potential to dramatically increase results, this supplement has virtually no side effects. This is part of what makes it so attractive to athletes. And, as we’ll see in the following section, testolone also has some surprising additional benefits.
Obviously, just like the rest of the SARMS, testolone presents very good opportunities to those with muscle wasting diseases, sarcopenia (age related muscle loss), and androgenic deficiencies. Unlike anabolic steroids, which are used for the same purposes, patients will be able to take advantage of the same positive effects, while avoiding most of the undesired effects.
Logically, testolone can render incredible benefits to an athlete without the cost of prominent side effects seen with anabolic androgenic steroids. Particularly, testolone will drastically improve one's endurance and recovery, which will further lead to a considerable increase in muscle mass and strength. Consequently, RAD140 will be a great addition to any sort of cycle, where it will give all of these qualities without any additional side effects. Besides, it can be successfully used solo in a long cycle, since it causes no suppression.
The recommended dosages of RAD140 vary from 20 to 30 milligrams (mgs) per day, and the optimal cycle duration is 12-14 weeks.
As a research chemical, RAD140 should come in liquid form to be taken orally. It is important to drop the liquid directly into the mouth, as it may stick to the walls of the glass if mixed with liquids. After dropping it into the mouth, you can chase it down with water or grape juice. Due to the relatively long half life, RAD140 can be dosed just once per day, and there is no need to be taking it several times per day.
While the often-discussed benefits of testolone include increasing muscle mass, reducing fracture risk, and improving the strength of tendons and ligaments (and doing so with few to no side effects), this compound offers some surprising benefits. Thus far, testolone also appears to be one of the best SARMs for energy support, endurance, and explosive power. This means that it can be useful for endurance sports as well as for fat loss and cardio-intensive training.
One of these benefits for male users is the fact that post-cycle therapy, or PCT, is not generally needed. When a bodybuilder or other athlete uses anabolic steroids, the inundation of androgens suppresses natural testosterone. Post-cycle therapy works to reduce the estrogen in the body and restore natural testosterone production. However, purchasing aromatase inhibitors and/or selective estrogen receptor modulators (SERMs) for PCT is an additional expense and hassle that most users of SARMs can avoid. It is important to note that some users of testolone and other SARMs do opt to run PCT afterwards. This is not generally necessary, though.
Using testolone, unlike using anabolic steroids, does not cause enlargement of the prostate or dangerous effects on cardiac health. It does not cause testosterone suppression and also does not cause gynecomastia. This is because it is not converted to estrogen. This benefit is key for male bodybuilders, as once gynecomastia becomes severe, it necessitates surgical treatment. This surgery can cause downtime and can be expensive as well.
As noted above, testolone offers female bodybuilders several benefits. One is the fact that, while it supports muscle growth and is highly anabolic, it doesn’t cause acne, clitoral enlargement, facial hair growth, or deepening of the voice. Testolone’s protective effects on bone may be of special interest to women. This is because women are generally more pone to osteoporosis than men are.
Testolone manages to spare its users virtually all of the negative effects of anabolic steroids. But one of the most important effects it avoids is that of liver toxicity. Steroids have an attached methyl group, which is toxic to the liver. Testolone and other SARMs, on the other hand, are non-methylated, meaning they are not toxic to the liver at all. In a similar vein, testolone does not cause the cholesterol imbalances that steroids can cause.
Studies in rats have indicated that testolone may protect neural tissue against neurodegenerative diseases. This indicates that it may have the potential to be used as a preventative measure against Alzheimer’s and similar diseases. While this benefit is not directly connected to bodybuilding or performance in other sports, it nonetheless indicates that RAD 140 has the potential to protect general health.
Testolone has several health benefits, but it also has a few convenience benefits. For one, it is taken orally. Like most research chemicals, RAD 140 has a generally unpleasant taste. However, taking it orally eliminates the potential pain and hassle of injection. As noted above, it also can be purchased legally.
While testolone and other SARMs may not give users the same results that a high dose of trenbolone or other highly anabolic steroid would, the results are generally somewhat comparable. The results from RAD 140 also are generally free of side effects. They may even offer protective effects against a variety of potentially damaging conditions.
RAD140 is perfect for cutting because it promotes the loss of fat tissue. The higher the dose, the more fat you’re likely to lose. It won’t give you a free license to eat whatever you want but if you’re disciplined you’ll see great results.
It’s also useful during a cutting cycle when you’re on a restricted calorie intake. Because RAD140 for cutting also promotes lean tissue gains, it can help you to hang on to your muscle and minimize catabolism too.
You wouldn’t choose RAD140 for bulking as your first option as there’s other drugs out there which are better at adding sheer mass.
RAD140 won’t give you enormous gains nor puff up your muscles, but you will find that it helps you to pack on pure muscle, with no added fat. This can be a useful component to a bulking cycle, helping to ensure that you gain quality mass and not just water.
One of the most appealing aspects of RAD140, and all of the SARMS in general, is the absence of side effects, making them some of the safest performance enhancing drugs (PED) these days. As mentioned above, RAD140 will not cause suppression, nor will it cause any of the side effects commonly associated to steroids.
What's more, in spite of being oral compounds, SARMS are not liver toxic, and so is RAD140. Finally, testolone does not interact with the aromatase enzyme, so there will be no estrogenic side effects when using it as a stand-alone PED, or with other non-aromatizing compounds.
Similarly, to other SARMs, one of the biggest benefits of RAD140 is that there are virtually no side effects noted. It is worth bearing in mind however that this drug is extremely new and more information about the long term effects may become known as time passes.
What is known is that RAD140 doesn’t aromatise and doesn’t cause any of the androgenic side effects which are seen with testosterone and other anabolic steroids. You won’t see RAD140 causing gyno or bloating.
No links have been shown between RAD140 and hair loss nor any impact on the libido or mood.
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