Synephrine can be found in the fruit of a plant known as Citrus aurantium. It is one of the main active compounds found in the fruit and is also known as green orange, or zhi shi in Chinese. It is also called sour orange or bitter orange in other parts of the world.
Chemically speaking, synephrine is chemically similar to the pseudo-ephedrine and ephedrine compounds that can be located in many of the over-the-counter cold and allergy medications. It is also found in a variety of weight loss and energy supplements that contain Ma Huang.
Those that use synephrine claim a myriad of benefits. This can include increasing metabolic rates, an increase of caloric expenditure (the quickness in which you lose calories), increasing of energy levels, as well as synephrine acting as a fat burner and as a promoter of weight loss.
The theory is that because synephrine acts as a stimulant, much like caffeine, it is believed to have some of the same effects in terms of an energy boost, as well as increasing metabolic rates and suppressing appetites. In Chinese medicine, zhi shi is used to help stimulate energy. While synephrine and many of the components that can be found in zhi shi appear to be the same as the ones found in ephedrine, synephrine is believed to work as a stimulant without leaving the negative side effects that inflict the central nervous system like ephedra does.
Zhi shi is also believed to help stimulate the metabolism in your body without the negative cardiovascular side effects that are experienced by at least some people that take ephedra. This is through its stimulation through specific adrenergic receptors, including beta-3 (not 1 or 2).
Those that are looking to lose weight or increase their energy can possibly reap the benefits from supplementing with synephrine. However, those that have cardiovascular problems should not take synephrine – more on potential side effects are listed below.
Remember that supplements don”t build great physiques. Dedication to proper training and nutrition does.
That said, here”s what you can expect from synephrine supplementation:
A slight increase in your basal metabolic rate.
A slight decrease in the activity of fat cell receptors that prevent fat mobilization.
A slight increase in the thermic effect of food, or the “energy cost” of metabolizing food.
If you know how to drive fat loss with proper diet and exercise, certain supplements can accelerate the process.
Based on my experience with my own body and having worked with thousands of people, I feel comfortable saying that an effective fat loss supplementation regimen can increase fat loss by about 30 to 50% with little to no side effects.
That is, if you can lose 1 pound of fat per week without supplements (and you can), you can lose 1.3 to 1.5 pounds of fat per week with the right ones.
Another big benefit of taking the right fat loss supplements is they are particularly effective for reducing stubborn fat, which is usually belly fat for us guys and hip and thigh fat for girls.
The clinically effective dosage of a supplement is the amount used in the scientific studies proving the benefits.
You see, it’s not enough to just know that synephrine can improve fat loss. You need to know how much is needed to see results.
And when you review the literature, you find a wide variety of dosages of synephrine used for weight loss purposes.
The most effective dosages were in the range of 25 to 50 milligrams per day, though, with 50 milligrams significantly outperforming 25 milligrams.
Several studies have demonstrated that synephrine doesn’t increase blood pressure, and research shows that it is generally safe and well tolerated.
The reality is if you’re like most people, you’re not going to notice much when you take synephrine. Most report a slight increase in energy with none of the downsides generally associated with stimulants (jitters, nausea, rapid heartbeat, etc.).
That said, if you have any medical conditions or take any medications that might contraindicate supplementation with synephrine, consult your doctor before use, of course.
Synephrine, as well as citrus aurantium extract have shown in animal studies to raise blood pressure. More studies are needed to prove or disprove the same effect in humans. It is recommended that while studies on the efficacy, safety, and pharmacology of citrum aurantium as a thermogenic supplement are still being performed, you should treat the substance as supplement with tame stimulant properties. As such, it should be avoided by individuals with cardiovascular-related inflictions, like hypertension.
When taken with other stimulants, large amounts of Synephrine use could possibly heighten the risk of hypertension, heart attack and other serious side effects. Research has found that Synephrine in itself does not raise blood pressure, but there is still a need for more research when it is used with other stimulants like caffeine.
There is an online report of a panic attack induced by use of a Synephrine stacked supplement, containing a host of other stimulants including phenylethylamine and caffeine in high concentrations.
Reports of side effects from Synephrine use alone include triggering headaches and migraines in some people.
It is recommended to consult your physician if you are planning to consume any other stimulants in addition to Synephrine.
Synephrine supplementation may cause:
Increase in heart rate (tachycardia)
Palpitations (awareness of one’s heart beating)
Increase in blood pressure
Increased risk of stroke
Increased risk of adverse cardiac events like cardiac arrhythmias
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