Testosterone undecanoate is used in men who do not make enough of a natural substance called testosterone. In males, testosterone is responsible for many normal functions, including growth and development of the genitals, muscles, and bones. It also helps cause normal sexual development (puberty) in boys. Testosterone belongs to a class of drugs known as androgens. It works by affecting many body systems so that the body can develop and function normally. Testosterone may also be used in certain adolescent boys to cause puberty in those with delayed puberty. This medication should not be used in women.
Testosterone Undecanoate is the undecanoate ester form of the androgen testosterone, with gonadotropin-secretory inhibiting and hormone replacement activity. As testosterone inhibits the secretion of gonadotropins from the pituitary gland, administration of testosterone decreases the secretion of luteinizing hormone (LH). By inhibiting LH secretion, the growth of Leydig cells, which are normally stimulated by LH to produce testosterone, may be suppressed. In addition, this agent promotes the maintenance of male sex characteristics and can be used for testosterone replacement in hypogonadal males.
Take this medication by mouth, usually twice daily with breakfast and with an evening meal, or as prescribed by your doctor. Swallow the capsules whole. Do not chew or open the capsules. Doing so can change how well the medication works.
Dosage is based on your medical condition, testosterone blood levels, and response to treatment.
Use this medication regularly in order to get the most benefit from it. To help you remember, take it at the same times each day.
Misuse or abuse of testosterone can cause serious side effects such as heart disease (including heart attack), stroke, liver disease, mental/mood problems, abnormal drug-seeking behavior, or improper bone growth (in adolescents). Do not increase your dose or use this drug more often or for longer than prescribed. When testosterone is misused or abused, you may have withdrawal symptoms (such as depression, irritability, tiredness) when you suddenly stop using the drug. These symptoms may last from weeks to months.
Tell your doctor if your condition does not improve or worsens.
Medically, Andriol dosages are prescribed in the range of 120 – 160 mg per day for the first 2 to 3 weeks. Following this initial period, prescription guidelines call for a reduction of Andriol dosage to a maintenance schedule of 40 – 120mg per day.
For performance and physique enhancement, the Andriol dosage must understandably be far greater. A minimum of 250mg per day is required (6 or 7 capsules) to see any measurable effect, and many individuals claim that the results at this range are on the low end. Commonly, Andriol is used at a dosage of 400 – 500 (10 – 14 capsules) per day. Advanced or experienced users may require even higher dosages than that.
Due to the lipophilic nature of Andriol’s pharmacology, it is recommended that Andriol dosages be administered with the consumption of food / meals, ideally with a higher fat content in order to maximize its absorption in the body through the lymphatic system. When taken on an empty stomach, studies have demonstrated extremely low absorption and bioavailability of Andriol. Andriol dosages should also be split into two evenly spaced dosages (e.g. morning and evening) in order to maintain steady and stable blood serum levels of Testosterone.
If you have liver disease, testosterone undecanoate may cause the buildup of extra fluid in your body (edema). This drug may also cause more liver damage and make your liver disease worse.
If you have heart disease, testosterone undecanoate may cause the buildup of extra fluid in your body (edema). Also, testosterone undecanoate may increase your cholesterol level, which may lead to more heart problems.
If you have kidney problems, testosterone undecanoate may cause the buildup of extra fluid in your body (edema).
If you are a man with breast cancer, you should not receive testosterone undecanoate. Taking this drug can make your breast cancer worse.
If you are a man with prostate cancer, you should not receive testosterone undecanoate.
Testosterone undecanoate is a category X pregnancy drug. Category X drugs should never be used during pregnancy. Women of childbearing age should use reliable birth control while taking this drug.
If this drug is used in pregnancy or if the patient becomes pregnant while taking this drug, the patient should be made aware of the potential harm to the fetus.
It is not known how much testosterone undecanoate passes into breast milk.
Testosterone undecanoate should not be used in women who are breast-feeding.
If you are older than 65 years, you may be at a higher risk of heart disease, prostate cancer, and enlarged prostate while taking this drug. This drug shouldn’t be used to treat age-related decreases in testosterone. There isn’t enough information from clinical trials in people aged 65 years and older to support the use of this drug for a long period.
Testosterone undecanoate can cause a severe allergic reaction. Symptoms can include:
swelling of your throat or tongue
If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 9-1-1 or go to the nearest emergency room.
Taking this drug again if you’ve ever had an allergic reaction could be fatal (cause death). Be sure to tell your doctor if you’ve ever had an allergic reaction to this drug.
Being that Andriol is a Testosterone product, it does carry with it all of the major side effects of Testosterone in general.
Estrogenic side effects are the first in particular to usually affect the user. Testosterone undergoes a moderate rate of aromatization (conversion) into Estrogen in the body via interaction with the aromatase enzyme. This means that blood plasma levels of Estrogen can and do build up with the use of Andriol, and Estrogenic side effects can result. Estrogenic side effects include: retention and/or gain of body fat, bloating and water retention, heightened blood pressure (as a result of water retention), and the potential for developing gynecomastia (breast tissue). It is recommended that individuals using Andriol look into the possibility of using some form of anti-estrogen during a cycle, or at the very least have anti-estrogens on hand in the event that Estrogenic side effects become prominent.
The next major Andriol side effects include androgenic side effects. These are masculinizing and male secondary sex characteristic related side effects. Being that Andriol is Testosterone, and Testosterone is the primary male androgen, it has direct influence on androgenic side effects. Furthermore, the high androgenicity of Testosterone products is more attributable to its reduction (or conversion) into Dihydrotestosterone (DHT), which is a far more potent androgen than Testosterone itself. In this case, the use of a 5-alpha reductase inhibitor can mitigate androgenic side effects by way of preventing or reducing the conversion of Testosterone into DHT. Androgenic side effects include: increases in aggression, increased body hair growth, increased oily skin secretions, deepening of the voice, and possible male pattern baldness (MPB) in those men that are genetically predisposed to it.
Testosterone, like any and all other anabolic steroids, can and will suppress natural endogenous Testosterone production. Testosterone suppression is a very real fact of anabolic steroid use, which is why it is important to limit cycle lengths and engage in proper Post Cycle Therapy (PCT) protocol following the termination of an anabolic steroid cycle. Failure to do so can potentially result in permanent Testosterone suppression for life.
Negative cardiovascular effects are also a concern. Research has shown that while Testosterone used in therapeutic dosages for the treatment of TRT in men are unlikely to increase the risk of cardiovascular problems (and might even possibly improve cholesterol profiles), the use of Testosterone at performance enhancing dosages does result in a decrease of HDL (the ‘good’ cholesterol). Furthermore, when combined with aromatase inhibitors, research and studies have shown that the negative effects on the cardiovascular system increase by a dramatic degree.
Andriol, due to its vastly different mechanism of action compared to C-17 alpha alkylated oral anabolic steroids, presents absolutely no hepatotoxic effects. For example, one study analyzed Andriol’s potential for liver toxicity by attempting high dosages on test subjects (400mg daily) for 20 days, and Andriol generated no notable changes in liver enzyme readings during the study. This also includes patients who have been administered the drug in the long-term (a decade or longer).
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