Vardenafil hydrochloride also known by the brand name Levitra, is a prescription medication that treats male erectile dysfunction.
Erectile dysfunction is when a man is unable to get or sustain an erection. It usually happens because the arteries that carry the blood to the penis are too narrow.
Vardenafil hydrochloride increases blood flow to the penis.
Its action is similar to that of sildenafil, or Viagra, but Viagra lasts between 2 and 4 hours, while Levitra lasts 4 hours.
Each orange, film-coated, round tablet, embossed with "BAYER" cross on one side and "5" on the other side, contains vardenafil hydrochloride equivalent to 5 mg of vardenafil. Nonmedicinal ingredients: anhydrous colloidal silica, crospovidone, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, red ferric oxide, titanium dioxide, and yellow ferric oxide.
Each orange, film-coated, round tablet, embossed with "BAYER" cross on one side and "10" on the other side, contains vardenafil hydrochloride equivalent to 10 mg of vardenafil. Nonmedicinal ingredients: anhydrous colloidal silica, crospovidone, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, red ferric oxide, titanium dioxide, and yellow ferric oxide.
Each orange, film-coated, round tablet, embossed with "BAYER" cross on one side and "20" on the other side, contains vardenafil hydrochloride equivalent to 20 mg of vardenafil. Nonmedicinal ingredients: anhydrous colloidal silica, crospovidone, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, red ferric oxide, titanium dioxide, and yellow ferric oxide.
Tadalafil/Cialis raw powder,the material of Vardenafil hydrochloride,a kind of White powder,many steroids products supplier usually buy high purity Vardenafil hydrochloride powder online,make it into all kinds of brand finished Vardenafil hydrochloride,the detail of the Vardenafil hydrochloride raw in SZOB as below:
Molecular Formula: C22H19N3O4
Molecular Weight: 389.4
Melt Point: 298-300°C
Storage Temp.: RT
Color: White Powder
Vardenafil hydrochloride can help a man get and maintain an erection.
During a penile erection, the penis fills with blood.
The blood vessels that supply the penis with blood expand, or dilate, and the vessels that take blood away from the penis contract. The two large chambers in the penis, known as the corpus cavernosa, fill with blood.
As the blood accumulates in the penis, an erection results.
Vardenafil hydrochloride belongs to a class of drugs called phosphodiesterase type-5 (PDE5) inhibitors. A PDE5 inhibitor stops PDE5 from constricting the arteries.By relaxing the arteries, vardenafil hydrochloride enhances blood flow when a man is sexually aroused.
The active ingredient works on the chain of reactions within the penis during arousal.
When a male is sexually aroused, nitric oxide is released into his penis, and this triggers a chain of reactions.This causes an enzyme, guanylate cyclase, to produce cyclic guanosine monophosphate (cGMP).cGMP regulates the contraction and dilation, or expansion, of blood vessels that carry blood to and from the penis.
The chemical reaction causes the vessels that supply the penis to dilate, while those removing blood from the penis contract.Phosphodiesterase-5 (PDE5), another enzyme breaks down or destroys cGMP.When cGMP is destroyed, the blood vessels return to their normal size, effectively ending the erection. Vardenafil hydrochloride stops PDE5 from destroying cGMP. In this way, it allows cGMP to work for longer. As a result, it helps prolong an erection.
Mechanism Of Action
Penile erection is a hemodynamic process initiated by the relaxation of smooth muscle in the corpus cavernosum and its associated arterioles. During sexual stimulation, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum. Nitric oxide activates the enzyme guanylate cyclase resulting in increased synthesis of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the corpus cavernosum.
The cGMP in turn triggers smooth muscle relaxation, allowing increased blood flow into the penis, resulting in erection. The tissue concentration of cGMP is regulated by both the rates of synthesis and degradation via phosphodiesterases (PDEs). The most abundant PDE in the human corpus cavernosum is the cGMP-specific phosphodiesterase type 5 (PDE5); therefore, the inhibition of PDE5 enhances erectile function by increasing the amount of cGMP. Because sexual stimulation is required to initiate the local release of nitric oxide, the inhibition of PDE5 has no effect in the absence of sexual stimulation.
Vardenafil hydrochloride may be taken with or without food.But do not drink large amounts of alcohol before sexual activity. Because alcohol can make it more difficult to get an erection,Moderate amounts of alcohol (2 drinks for a 70 kg person) will not interfere with the medication.
It is important to take this medication exactly as prescribed by your doctor. Do not take higher doses of this medication than prescribed by your doctor. Things you need to attention as below:
Before you take Vardenafil hydrochloride
You are not allowed to take Vardenafil hydrochloride if you:
² are allergic to vardenafil or any ingredients of this medication
² are taking (or have taken in the past 24 hours) any medication that contains nitrates (e.g., amyl nitrite "poppers," isosorbide mononitrate, isosorbide dinitrate, nitroglycerin)
² are taking indinavir or ritonavir (for HIV infection)
² are taking ketoconazole or itraconazole (for fungal infections)
² are taking the medication riociguat (for high blood pressure in the lungs)
² have had an episode of non-arteritic anterior ischaemic optic neuropathy (NAION), an eye condition that is caused by loss of blood flow to the optic nerve
² Nitrates are found in medications that are used to treat angina (chest pain). If you are not sure if you are taking nitrates, ask your doctor or pharmacist before taking it. Nitrates must NOT be taken by anyone who is using Vardenafil hydrochloride because they can cause your blood pressure to drop very low. This may cause dizziness, fainting, heart attack, or stroke.
Vardenafil hydrochloride is usually taken only when needed, about 60 minutes before sexual activity. The medicine can help achieve an erection when sexual stimulation occurs. An erection will not occur just by taking a pill. Follow your doctor's instructions.
Do not take this medicine more than once a day. Allow 24 hours to pass between doses.
Contact your doctor or seek emergency medical attention if your erection is painful or lasts longer than 4 hours. A prolonged erection (priapism) can damage the penis.
Keep this medication out of reach and sight of children. This medication should be stored in its original package, at room temperature between 15°C and 30°C.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Do not take Vardenafil hydrochloride with similar medicines such as avanafil (Stendra), sildenafil (Viagra), or tadalafil (Cialis). These medicines also have other brand names (Adcirca, Revatio) that are used to treat a condition called pulmonary arterial hypertension.
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Vardenafil hydrochloride especially:
all other medications you use for erectile dysfunction;
an antibiotic - clarithromycin, erythromycin, telithromycin, and others;
antifungal medicine - itraconazole, ketoconazole, and others;
drugs to treat high blood pressure or a prostate disorder - alfuzosin, doxazosin, prazosin, silodosin, terazosin, tamsulosin;
heart rhythm medicine - amiodarone, dofetilide, disopyramide, dronedarone, procainamide, quinidine, sotalol; or
HIV/AIDS medicine - atazanavir, indinavir, ritonavir, saquinavir, and others.
This list is not complete. Other drugs may interact with Vardenafil hydrochloride, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Vardenafil hydrochloride is available in tablets of 2.5 milligrams (mg), 5 mg, 10 mg, and 20 mg.
The usual recommended dose is one 10 mg tablet taken as needed, 25 to 60 minutes before sexual activity. This medication has been shown to be effective within 15 minutes of taking the tablet, and lasts up to 8 to 10 hours later. As the amount of time Vardenafil hydrochloride takes to work varies from person to person, starting sexual activity at different times after taking the tablet will determine the optimal time for sexual activity. It is not recommended to take more than one dose per day. Your doctor may recommend a dose as low as 5 mg or as high as 20 mg.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
when you take the drug,these factors may affect how you should use this medication.
Alcohol: Consumption of alcohol in large amounts may decrease the ability to get an erection and may also temporarily decrease blood pressure, causing dizziness and fainting.
Blood pressure: Tell your doctor if you are taking medications to treat high blood pressure, as the combination of these medications with vardenafil may add to the blood pressure-lowering effect of these medications. If you have low blood pressure, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Grapefruit juice: Grapefruit juice can increase the amount of vardenafil in your bloodstream. Do not drink grapefruit juice when taking this medication.
Hearing problems: If you experience a sudden decrease or loss of hearing you should seek medical attention immediately.
Heart conditions: Men who have or have had heart disease or a heart attack or stroke should speak to their doctor before taking any medication for erectile dysfunction. If chest pains, dizziness, or nausea are experienced during sex, the exertion should be stopped and your doctor informed.
Liver function: Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Lower doses of this medication may be necessary.
Nitrate-containing medications: Vardenafil should never be taken with any medications that contain nitrates. Blood pressure may drop to life-threatening levels if vardenafil is taken with any nitrate-containing medication (e.g., nitroglycerin tablets, spray, or patches) or any other nitrates (e.g., isosorbide dinitrate or amyl nitrite "poppers").
This rare condition is more likely to occur if you have heart disease, high blood pressure, high cholesterol, diabetes, or eye problems.
Some side effects of Vardenafil hydrochloride such as stuffy nose, sneezing, and a warm feeling or redness in the face, neck, arms, and upper chest may go away as your body adjusts to the medicine. While these side effects do not usually need medical attention, talk to your doctor if they become bothersome.
Check in with your doctor right away if you notice any of these side effects while taking Levitra:
Pain in the arm, back, or jaw
Blindness, blurry vision, or decreased vision
Pain, discomfort, or tightness in the chest
Chills, cold sweats
Dizziness, lightheadedness or faintness
Racing, pounding heartbeat pr pulse
Skin rash or puffiness or swelling of eyelids, face, lip, tongue, eyes
Unusual tiredness or feeling of weakness
Rare Side Effects of Levitra
Some Levitra side effects are less common, including:
Pain in the back or other areas
"Pins and needles" sensation of the skin
Dry, sore throat
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|White or off white or light yellow crystalline powder|
|soluble in acetone, ethanol, ethyl ether, ethyl acetate, insoluble in water|
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