yohimbine hcl powder (146-48-5)

yohimbine hcl powder (146-48-5)
Product Details


1. What Is Raw yohimbine hcl powder?


Yohimbe (Pausinystalia johimbe) is a tree that grows in western and central Africa;yohimbine was originally extracted from the bark of yohimbe in 1896 by Adolph Spiegel.In 1943 the correct constitution of yohimbine was proposed by Witkop.Fifteen years later, Van Tamelen used a 23-step synthesis to become the first person to achieve the synthesis of yohimbine. Yohimbine is an indole alkaloid derived from the bark of the Pausinystalia yohimbe tree in Central Africa. It is a veterinary drug used to reverse sedation in dogs and deer.


Treats erectile dysfunction: In some countries, the extract is used as a prescription drug to treat erectile dysfunction. A 2002 study in Germany found that pro-erectile effects of the bark extract may predominantly be caused by the yohimbe. But it’s unclear if the yohimbe is enough on its own to help.


Aids in fat loss: Yohimbe and other alkaloids in the bark extract are said to block specific receptors that actually inhibit fat loss. A three-week study in 1991 observed 20 obese females on 1,000-calorie diets. They were given 20 mg of yohimbe each day and lost three pounds more than the group receiving placebos. 


Not a drastic weight loss, but enough to give experts hope that yohimbe can help with weight loss. Other studies have found that yohimbe increases the amount of non-esterified fatty acids, a result of fat breaking down. More research is needed. Most other studies in the field are done using the drug yohimbine. 


Extracted chemicals are not the same as yohimbe bark. Studies with yohimbine are expected to give different results than studies that used the raw plant.





2. How Does Raw yohimbine hcl powder Works?


Yohimbe is derived from the bark of a west African evergreen tree. Yohimbine is an active chemical (an alkaloid) found in said bark and is cultivated into supplement form. Yohimbine hydrochloride is a standardized form of yohimbine that is available as a prescription drug in the United States. These terms are all related but are interchangeable.


Yohimbe contains a chemical called yohimbine which can increase blood flow and nerve impulses to the penis or vagina. It also helps counteract the sexual side effects of certain medications used for depression.


Yohimbine has high affinity for the α2-adrenergic receptor, moderate affinity for the α1 receptor, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1F, 5-HT2B, and D2 receptors, and weak affinity for the 5-HT1E, 5-HT2A, 5-HT5A, 5-HT7, and D3 receptors.[13][14] It behaves as an antagonist at α1-adrenergic, α2-adrenergic, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, and D2, and as a partial agonist at 5-HT1A. Yohimbine interacts with serotonin and dopamine receptors in high concentrations.


Yohimbine blocks the pre- and post-synaptic α2 receptors. Blockade of post-synaptic α2 receptors causes only minor corpus cavernosum smooth muscle relaxation, due to the fact that the majority of adrenoceptors in the corpus cavernosum are of the α1 type. Blockade of pre-synaptic α2 receptors facilitates the release of several neurotransmitters in the central and peripheral nervous system — thus in the corpus cavernosum — such as nitric oxide and norepinephrine.


Whereas nitric oxide released in the corpus cavernosum is the major vasodilator contributing to the erectile process, norepinephrine is the major vasoconstrictor through stimulation of α1 receptors on the corpus cavernosum smooth muscle. Under physiologic conditions, however, nitric oxide attenuates norepinephrine vasoconstriction.


Yohimbe supplements often list yohimbe bark extract or yohimbine as the active ingredient. However, some of these products might not provide accurate information about the amount of yohimbine in the supplement. Also, some yohimbe supplements list yohimbine hydrochloride as an active ingredient. Yohimbe products containing man-made yohimbine hydrochloride as an ingredient are not legal to sell as a dietary supplement in the US.


 Because yohimbine is associated with many side effects, check with your health care provider before taking yohimbe bark if you have any chronic health problems or take any prescription medications.





3. How to Use Raw yohimbine hcl powder?


Yohimbe is the name of an evergreen tree found in parts of central and western Africa. The bark of yohimbe contains a chemical called yohimbine, which is used to make medicine. Yohimbine hydrochloride (Aphrodyne, Yocon) is a form of yohimbine that is a prescription drug in the US.


Yohimbe is taken by mouth arouse sexual excitement, for erectile dysfunction (ED), sexual problems caused by medications for depression called selective-serotonin reuptake inhibitors (SSRIs), and general sexual problems in both men and women. It is also used for athletic performance, weight loss, exhaustion, chest pain, high blood pressure, low blood pressure that occurs when standing up, diabetic nerve pain, and for depression along with certain other medications.


Recently yohimbe, or more accurately, its active ingredient yohimbine, has been the subject of some heated debates among fitness enthusiasts and industry insiders alike. While it was originally considered a flop of a supplement, because it did not increase testosterone levels as first suspected, it had developed a bit of a cult following by some men for its reported ability to increase support sexual health.


However, some supplement manufacturers have recently claimed that it can also aid in the loss of "stubborn fat." You know; those areas that just won't lean out no matter how hard you diet and exercise. Typically, these areas are located in the midsection of men, and on the glutes and thighs of women.


A dose of yohimbine that’s too big could drop your blood pressure, cause dizziness, facial flushing and nausea,” warns Fratellone. Yohimbine and yohimbe bark may also increase heart rate and raise blood pressure. “No one should experiment with herbs without talking to their doctor,” reminds Fratellone. 


“If you’re taking Flomax and you start taking yohimbe, you’re going to dilate your penal vessels and you’ll pee more.” Other potential interactions between yohimbe and other drugs and herbs should be considered. Some of these combinations may be dangerous.




 

4. Dosage of Raw yohimbine hcl powder


Ed dosage for Yohimbine HCl is around 4-8 mg per dose. This can be taken around two to three times per day. Yohimbine has a very short half-life and is eliminated in under 1 hour.


Yohimbine has a varying rate of absorption which appears to have something to do with what’s in your stomach when you take it. It is more effective to take Yohimbine HCl on an empty stomach.


Before taking this medication, tell your doctor if you are taking a medicine for depression, mania, or another psychiatric condition. Generally, yohimbine should not be used with these medicines.


Drugs other than those listed here may also interact with yohimbine or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.


In conclusion, Yohimbine HCl is a great dietary supplement for a number of benefits. It is used mostly as an aphrodisiac and in promoting men’s vitality and men’s sexual health. However, it also has the potential to help maintain a healthy weight and possibly to improve cognition. Yohimbine HCl is a very strong extract from the Yohimbe plant in Central Africa.


The recommended dosage is around 4-10 mg, twice daily.At the recommended dosage most users do not experience and side effects. However, serious negative effects can occur at high doses and we urge you to not exceed the recommended dosage.





5. Warning of Raw yohimbine hcl powder


Do not use while taking any medications, or if other medical problems exist, such as; angina pectoris, depression, other psychiatric illness, heart disease, high blood pressure, kidney disease, or liver disease. Do not exceed the recommended dosage for Yohimbine, as an overdose could, in extreme cases, result in death. Generally, yohimbine is not recommended for use by females for libido enhancement, and certainly is not to be used during pregnancy. [Note that a group of researchers conducted a study using yohimbine in women with decreased libido, and observed that the yohimbine supplementation was not effective in supporting their sexual health.


the researchers did determine that the inclusion of yohimbine along with the caffeine, did evoke some potentially dangerous changes in the cardiovascular system. They concluded that the addition of yohimbine should be treated with caution, and must be excluded in particular obese individuals with cardiovascular complications.


Dating back centuries, Western African civilizations have believed in the medicinal powers of the bark from the yohimbe tree native to their land. Its earliest uses in these areas was as an aphrodisiac for women, and this use continues today. Yohimbine is the active ingredient in yohimbe and what gives it its medicinal properties, according to MedlinePlus. However, women considering yohimbe supplements should be aware that the amount of yohimbine contained in supplements can vary substantially and some may contain very little. Before using yohimbe, consult with a trusted health practitioner who can advise you of potential benefits and risks.


Take yohimbine exactly as directed. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.


Yohimbine is usually taken three times a day. Follow your doctor's instructions.

Store this medication at room temperature away from moisture and heat.

If miss a dose, skip the missed dose if it is almost time for your next scheduled dose. Do not use extra yohimbine to make up the missed dose.


Symptoms of a yohimbine overdose include increased blood pressure (severe headache, blurred vision, flushing); a fast heart rate; numbness or tingling; runny nose; tremor; anxiety; poor coordination; and confusion or abnormal behavior.


Seek emergency medical attention if overdose.

In most studies, no adverse effects were reported. However, in one study there were four side effects reported by both the Yohimbine group and the placebo group, which included itching, high blood pressure, headache, and difficulty sleeping.


There has been at least one case of neurotoxic effects after a very high dose of Yohimbine. A bodybuilder took around 5 grams of Yohimbine HCl before a competition. He suffered from a loss of consciousness and seizures. He recovered after 12 hours in a hospital.





6. What Are the Possible Side Effects of Raw yohimbine hcl powder?


Depending on dosage, yohimbine can either increase or decrease systemic blood pressure (through vasoconstriction or vasodilation, respectively). Because yohimbine has highest affinity for the α2 receptor, small doses can increase blood pressure by causing a relatively selective α2 blockade. Yohimbine also, however, interacts with α1 receptors, albeit with lower affinity; therefore, at higher doses an α1 blockade can occur and overwhelm the effects of the α2 blockade, leading to a potentially dangerous drop in blood pressure. Higher doses of oral yohimbine may create numerous side effects, such as rapid heart rate, overstimulation, anomalous blood pressure, cold sweating, and insomnia.


Before taking this medication, tell your doctor if you

have kidney disease;

have peptic ulcer disease (stomach ulcers);

are suffering from depression;

are being treated for a psychiatric condition; or

have any type of heart disease.

You may not be able to take yohimbine, or you may require a lower dose or special monitoring during therapy if you have any of the conditions listed above.

If you experience any of the following serious side effects, stop taking yohimbine and seek emergency medical attention:


an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

a very irregular or fast heartbeat; or

confusion or unusual behavior.

Other, less serious side effects are more likely to occur. Continue to take yohimbine and talk to your doctor if you experience

dizziness;


anxiety, irritability, or nervousness;

tremor (shaking);

headache; or

skin flushing.

This is not a complete list of side effects and others may occur.




 

7. Buy Yohimbine Powder from SZOB


→ Visit our online pharmacy and fill in an order of Yohimbine raw materials.

→ Define place of delivery, quantity of the product and the way of payment.

→ In the period of 30 minutes, you will receive a confirmation of your order.

→ It will be sent out within 12 hours.






yohimbine hcl powder video





Raw yohimbine hcl powder Specifications:



Name yohimbine hcl powder
Appearence White crystalline powder
Cas

 146-48-5

Assay ≥99.2%
Solubility Soluble in water (10 mg/ml), DMSO (25 mM), ethanol (~2.5 mg/ml), and methanol.

Loss on drying

≤1%

Heavy Metal

≤10ppm

Dosage

 4-8mg

Onset time              

 20 minutes

Grade

Pharmaceutical Grade





yohimbine hcl raw powder Competitive Advantage:


1 High quality with competitive price:

1) Quality Standard: USP 35


2) Purity: >99%


3) We are manufacturer and can provide high quality products with factory price.


2 Fast and safe delivery:

1) Parcel can be sent out in 24 hours after payment. Tracking number available


2) Secure and discreet shipment. Various transportation methods for your choice.


3 We have clients throughout the world:

1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.


2) Market feedback and goods feedback will be appreciated, meeting customers' requirement is our responsibility.


3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.


4 Three Principles

1)Safe delivery: Channel diversification,protect the privacy of customers.And just in case, ensure to re-ship.

 

2)Never change: The product will always maintain high purity, will not change,High quality is the culture of our company.

 

3)Good services: As quickly as possible to solve customer problems, so that customers receive the goods safely.





yohimbine hcl raw powder HNMR|SZOB


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